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During development the space between the sensory retina and the retinal pigment epithelium is obliterated when these two layers become apposed.  Visit: Normal histology and diseases of the retina

However, the sensory retina readily separates from the retinal pigment epithelium when the fluid (liquid vitreous humor, hemorrhage, or exudates) accumulates within the potential space between these structures. Such a separation is designated a retinal detachment.

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Three varieties of this common cause of blindness are recognized - Rhegmatogenous   ;    Tractional    ;     Exudative.

Rhegmatogenous retinal detachment:

Rhegmatogenous retinal detachment, the commonest form of retinal detachment, is associated with a retinal tear and often degenerative changes in the vitreous or peripheral retina.

Full thickness hole in the retina are usually not complicated by retinal detachment, unless liquid vitreous humor gains access to the potential space between the retina and the retinal pigment epithelium, and even then some vitreoretinal traction seems to be necessary for retinal detachment to occur.

Retinal detachment follows intraocular hemorrhage (as after trauma) and is a potential complication of cataract extractions and several other ocular operations.

Tractional retinal detachment:

In tractional retinal detachment, the retina is detached by being pulled towards the center of the eye by adherent vitreoretinal adhesions, as occurs in proliferative diabetic retinopathy and the retinopathy of prematurity, and after intraocular infection.

Exudative retinal detachment:

 An accumulation of fluid in the potential space between the sensory retina and the retinal pigment epithelium causes an “exudative retinal detachment” in disorders such as choroiditis, choroidal hemangioma, and the choroidal melanomas.

Factors predisposing to retinal detachment :

Factors include retinal holes (due to trauma or certain retinal degenerations), vitreous traction, diminished pressure on the retina (as after vitreous loss), and weakening of the fixation of the retina.  The photoreceptors and retinal pigment epithelium normally function as a unit.  After they separate in a retinal detachment, oxygen and nutrients that normally reach the outer retina from the choroid need to diffuse a greater distance, a situation which causes the photoreceptors to degenerate and cyst-like extracellular space to appear within the retina.

             

Natural history of asymptomatic clinical retinal detachments.Am J Ophthalmol. 2005 May;139(5):777-9.

PURPOSE: To determine the natural history of asymptomatic, clinical rhegmatogenous retinal detachment. DESIGN: Single observer, prospective, consecutive, observational case series. METHODS: Consecutive patients were included who were referred to the author's clinical practice with rhegmatogenous retinal detachment extending greater than two disk-diameters posterior to the equator. Patients whose eye had an intraocular procedure within the past year or who had a history of symptomatic retinal detachment in the fellow eye were excluded. Eighteen eyes of 16 patients were followed for an average of 46 months. The main outcome measure was progression of asymptomatic retinal detachment to symptomatic retinal detachment. RESULTS: None of the 18 asymptomatic, clinical, rhegmatogenous retinal detachments became symptomatic. The posterior margin of one retinal detachment slightly progressed 4 months into the study and then stabilized for 4 years and remained asymptomatic. CONCLUSIONS: Asymptomatic, clinical, rhegmatogenous retinal detachments can probably be safely observed for many years.

Analysis of symptoms associated with rhegmatogenous retinal detachments.Clin Experiment Ophthalmol. 2004 Dec;32(6):603-6.

AIM: The symptoms associated with rhegmatogenous retinal detachments are variable and can be associated with other vitreoretinal and neuro-ophthalmic entities. The present study sought to determine the frequency and type of symptoms associated with rhegmatogenous retinal detachment (RRD), and analyse any relationships with the premorbid state. METHODS: An observational case series was undertaken. A patient questionnaire together with clinical data was collected for patients presenting with RRD. RESULTS: The data on 141 patients presenting with RRD were evaluated prospectively. More than 90% of patients reported a variety of symptoms including visual loss, floaters and flashes. The speed of visual loss was not associated with the extent of retinal break. Rather unexpectedly, patients with a history of retinal pathology were not any more likely to be symptomatic either in their presenting or fellow eye. The absence of symptoms was not associated with age, high myopia or previous cataract surgery. CONCLUSION: Both patients and physicians need to be aware of the importance of the symptoms associated with RRD.

Diabetic tractional retinal detachment. Klin Monatsbl Augenheilkd. 2002 Apr;219(4):186-90.

Diabetic tractional retinal detachment is a severe complication in diabetic retinopathy. The decision for a surgical intervention has to consider the spontaneous course of the disease, intraoperative and postoperative complications and the expected functional results. An extramacular tractional detachment can remain stable for a long time and can be observed as long as the centre of the macula is not threatened. Traction to the macula can cause oedema and reduced vision, even if the macula itself is not detached. In these cases vitreous surgery can improve vision. Retinal breaks due to tractional membranes can cause a traction-rhegmatogenous retinal detachment which is usually rapidly progressive and requires early surgery. For cases with tractional detachment of the macula there is no alternative to surgery. In cases with long-standing and complete tractional detachment with severe retinal ischaemia the functional prognosis even after anatomically successful surgery is poor and it may be better not to operate.

Late recurrent retinal detachment after scleral buckling.J Fr Ophtalmol. 2006 Nov;29(9):991-3.

PURPOSE: To analyze the physiopathologic mechanism, therapeutic modalities, and prognosis of late recurrent retinal detachment. METHODS: A retrospective study was conducted on late recurrent retinal detachment operated with episcleral surgery over a 15-year period. Ten patients were included in this study. RESULTS: Late recurrent retinal detachments occurred in 0.39% of all retinal detachments repaired by episcleral surgery over 15 years. Redetachment occurred 3-7 years after surgery, with etiologies including new retinal breaks (seven cases), reopening of old breaks (three cases), and removal of scleral explant (one case). Proliferative vitreoretinopathy (PVR) grade B was seen in three cases, grade C in six cases, and grade D in one case. After reoperation, the retina was reattached in nine cases. Three eyes were treated with scleral buckle, the others underwent vitreoretinal surgery. Failure occurred in one patient who had a very high level of vitreoretinal proliferation. CONCLUSION: Late recurrent retinal detachments are rare and vitreous base traction seems to be an important factor, although the associated PVR was probably a secondary factor. Treatment depends on PVR, with vitreoretinal surgery necessary in some cases. They usually have a good prognosis.

Bilateral exudative retinal detachment as the first sign of relapsing acute myelogenous leukaemia.Clin Experiment Ophthalmol. 2006;34(6):623-5.

Bilateral exudative retinal detachment is rarely seen as an ocular manifestation of acute myelogenous leukaemia. Herein, a case is described where a trans-scleral choroidal biopsy was used to diagnose relapsing acute myelogenous leukaemia when the rest of her systemic work-up was negative.

Concentration of neuron-specific enolase and S100 protein in the subretinal fluid of rhegmatogenous retinal detachment.Graefes Arch Clin Exp Ophthalmol. 2005 Nov; 243(11):1167-74. Epub 2005 May 20.

BACKGROUND: Neuron-specific enolase and S100 protein are markers of neuronal lysis. To assess the neuronal suffering in rhegmatogenous retinal detachment we quantified neuron-specific enolase and S100 protein in the subretinal fluid. METHODS: The puncture was performed in the sclera with a Merseture 5/0 round needle, and the fluid was collected with a glass capillary tube. Twelve subretinal fluid samples were obtained from 12 eyes with rhegmatogenous retinal detachment undergoing retinal detachment surgery. Vitreous from ten eyes with macular hole or epimacular membrane served as negative control group, and vitreous collected during cornea procurement from ten deceased patients served as positive control group. RESULTS: The mean concentration of neuron-specific enolase (in nanogrammes per millilitre) was 602 in the subretinal fluid of rhegmatogenous retinal detachment, 10.2 in the serum of these patients, 2.9 in the vitreous of the negative control group, and 364 in the positive control group. The mean concentration of S100 protein (in nanogrammes per millilitre) was 104 in the subretinal fluid of rhegmatogenous retinal detachment, <0.1 in the serum of these patients and in the vitreous of the control negative group, and 11.18 in the positive control group. CONCLUSION: Neuron-specific enolase (NSE) and S100 are known to be good markers of brain stress and, thus, are good markers of retinal stress.

Bilateral exudative retinal detachments as the presenting features of idiopathic orbital inflammation.Clin Experiment Ophthalmol. 2005 Dec;33(6):671-4.

Idiopathic orbital inflammation, also known as orbital pseudotumour, is a term describing a spectrum of idiopathic, non-neoplastic, non-infectious, space-occupying orbital lesion without identifiable local or systemic cause. This disease occurs mainly in young adults and typically presents with acute proptosis, chemosis and limited extraocular movement. Herein an unusual case of idiopathic orbital inflammation presenting with bilateral exudative retinal detachment in a 9-year-old girl is described. It demonstrates that prompt diagnosis and corticosteroid treatment can yield good clinical response and significant visual recovery.

Rhegmatogenous retinal detachment in children and youth--chosen epidemiological features.Klin Oczna. 2004;106(3 Suppl):453-5.

PURPOSE: To assess chosen epidemiological features (risk factors) of rhegmatogenous retinal detachment in young patients. MATERIAL AND METHODS: Retrospective evaluation of patients aged up to 18 years with rhegmatogenous retinal: detachment hospitalized in the Department of Ophthalmology, University of Medical Sciences of Bydgoszcz--in the period between 1993-2003. Studied group comprised 37 patients aged from 2 to 18 years. Excluded were the patients with retinopathy of prematurity. RESULTS: Mean age in the group studied was 12.6 (SD=3.6) years, over 80% were male. In 88.9% at least one risk factor was found--the most common of which was history of trauma (52.7%). Myopia was diagnosed in 27.7% of cases, in 8.3% patients cataract surgery had been performed prior to retinal detachment. In 8.3% of patients in group studied revealed congenital structural abnormalities. One patient (2.8%) had toxocariasis. Bilateral retinal detachment occurred also in one patient. The macula was detached in 75% and total retinal detachment was present in 38.8% of cases. CONCLUSIONS: The most common risk factor in the group studied was history of nonsurgical trauma. Prevalence of macular detachment was noted.

Traction retinal detachment, optic atrophy, apallic syndrome after shaking trauma in an infant.Ophthalmologe. 2002 Apr;99(4):295-8.

INTRODUCTION: Ophthalmological examinations are important in children with suspected shaken baby and/or battered child syndrome. Retinal and epiretinal haemorrhages can indicate non-accidental injuries. We observed a case of extensive retinal hemorrhages, edema of the optic disc followed by development of optic atrophy, neovascularisation and tractional retinal detachment over the course of months. CASE REPORT: A 6-week-old infant with no history of systemic disease or trauma was admitted to the children's hospital because of a disorder of consciousness, respiratory insufficiency, taut fontanel and dilated pupils with sluggish reaction to light. A subdural haematoma was diagnosed. Ophthalmological examination showed no signs of trauma in the anterior segment. Ophthalmoscopy revealed extensive retinal haemorrhages and swollen optic nerve heads. During the next months optic atrophy, subretinal fibrosis at the posterior pole, neovascularisation at the optic disc and non-rhegmatogenous retinal detachment developed. The child is in a persistent vegetative state. DISCUSSION: Non-accidental injuries can cause direct trauma and indirect traumatic sequelae. Retinal haemorrhages, especially in conjunction with unexplained trauma or changes of consciousness should arouse suspicion of shaken baby syndrome. The ophthalmologist should emphasize this and strongly recommend further investigation if not previously undertaken.

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