Pancreatic Pathology Online

Pyloric Gland Adenoma of the Pancreas

Dr Sampurna Roy MD                July 2016

 

Pyloric gland adenoma is an uncommon benign tumour, similar to the pyloric gland type adenoma of the gallbladder.

Gross features:  The surgical resection specimen display a polypoid, bilobed mass attached to the wall of the main pancreatic duct by a thin fibrous stalk. 

Microscopic features:  Well-demarcated nodule composed of closely packed tubular glands lined by columnar, mucin-secreting cells with abundant clear cytoplasm and basally oriented nuclei.

Focal mild to moderate dysplastic changes may be present.

Pyloric metaplasia and focal papillary hyperplasia are often present in adjacent ductal epithelium

Histochemistry:  Periodic acid-Schiff reactions, with and without diastase predigestion, showed reactivity in the tubular glands,whereas alcian blue was negative.

Immunohistochemical features: Chromogranin, serotonin, somatostatin, and gastrin were negative.

The finding of a K-ras, codon 12 mutation and the presence of focal dysplasia may denote neoplastic potential in association with this lesion.

 

Further reading:

Intraductal tubular adenoma (pyloric gland-type) of the pancreas: a reappraisal and possible relationship with gastric-type intraductal papillary mucinous neoplasm.

Intraductal tubular adenoma, pyloric gland-type, of the pancreas

Intraductal tubular adenoma of the pancreas, pyloric gland type: a clinicopathologic and immunohistochemical study of 6 cases.

Intraductal tubular adenoma, pyloric gland-type, of the pancreas.

Pyloric gland-type tubular adenoma superimposed on intraductal papillary mucinous tumor of the pancreas. Pyloric gland adenoma of the pancreas.

Pyloric gland adenoma of the main pancreatic duct.

 

 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)


 

 

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