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Primary pulmonary rhabdomyosarcoma as a rare
differential diagnosis of small cell lung cancer.Pneumologie.
2005 Jul;59(7):456-60.
Primary
pulmonary rhabdomyosarcoma is a rare entity and the histological
differential diagnosis can be difficult. We report on a 43-year old
female patient, smoker (25 pack-years), in whom a large solitary
brain metastasis was diagnosed and enucleated. Histological
examination revealed a typical small cell carcinoma and histological
examination of biopsies obtained from a tumor in the left upper lobe
of the lung was compatible with a small cell carcinoma. Despite
chemotherapy there was a progressive tumor growth. Bronchial
biopsies again showed a small cell tumor, although
immunohistochemistry proved it to be a pleomorphic rhabdomyosarcoma.
Due to the progressive tumor growth with necrosis and superinfection
and a lack of further metastases lobectomy of the left upper lobe
was performed, complicated by postoperative pleural empyema,
limiting the possibilities of adjuvant therapy. Early relapse
occurred with pleural, pulmonary, chest wall and spinal metastases.
Laminectomy and extirpation of the spinal metastases, local
radiotherapy and chemotherapy with iphosphamide and doxorubicine led
to partial remission and clinical improvement for few months only.
The patient died from metastatic primary rhabdomyosarcoma of the
lung. This rare tumor mimicked small cell lung cancer. Appraisal of
the atypical clinical course and a close dialogue between
pathologists and clinicians enabled the correct diagnosis.
Primary
rhabdomyosarcoma of the lung arising over cystic pulmonary
adenomatoid malformation.
Pediatr Hematol Oncol. 2005 Sep;22(6):525-9.
The authors
report the case of a 2-year-old girl with pulmonary cystic
adenomatoid malformation type II who presented with a mass on the
lower lobe of the left lung. Resection and histological examination
revealed pleomorphic rhabdomyosarcoma. Chemotherapy and radiotherapy
followed the operation and the girl is alive and in perfect
condition 10 years after the operation. The literature on primary
rhabdomyosarcoma of the lung in children is reviewed.
Metastatic germ cell tumor of the lung masquerading as primary
rhabdomyosarcoma.Pathol
Int. 2005 Oct;55(10):649-54.
Two years after
testicular resection was carried out in a 40-year-old man that
revealed mixed germ cell tumor of more than one histological type (seminoma,
embryonal cell carcinoma, and yolk sac tumor), he presented with an
asymptomatic pulmonary nodule in his left lower lobe. Video-assisted
thoracoscopic partial resection of the tumor revealed a 24 x 20 mm
teratoma with somatic-type malignancy in which pleomorphic
rhabdomyosarcoma was a major element. One year later, asymptomatic
tumor recurrence occurred at both edges of the stapler line as 22 x
20 mm and 10 x 5 mm nodules composed only of pleomorphic
rhabdomyosarcoma. Throughout the course there was no abdominal lymph
node swelling detected by computed tomography (CT) and tumor markers
were normal. Adjuvant chemotherapy was started after the tumor
recurrence. Currently, the patient is still undergoing chemotherapy
5 months after the tumor recurrence. In conclusion, despite the fact
that primary pulmonary rhabdromyosarcoma is a rare neoplasm,
metastatic pulmonary germ cell tumor with somatic-type malignancy
showing predominantly rhabdomyosarcomatous differentiation should be
considered in the differential diagnosis of such lesions of the
lung.
Primary pulmonary
rhabdomyosarcoma arising within cystic adenomatoid malformation: a
case report and review of the literature.J
Pediatr Surg. 2001 Jul;36(7):1062-5
The current
report describes a 13-month-old boy with primary pulmonary
rhabdomyosarcoma (RMS) that originated within a congenital cystic
adenomatoid malformation (CCAM). To the best of our knowledge, he is
the youngest patient of all primary pulmonary RMS cases reported in
the English-language literature. The tumor, localized in left upper
lobe, was removed completely, and histologic examination showed
embryonal subtype. Postoperative systemic chemotherapy was carried
out. Recent evaluation 15 months after resection has not identified
any residual or recurrent disease. Primary pulmonary RMS, although
very rare in the pediatric age group, should be considered in young
patients with solitary pulmonary masses and associated cystic
lesions.
Embryonal
rhabdomyosarcoma of the lung arising in cystic adenomatoid
malformation: case report and review of the literature.
J
Pediatr Surg. 1997 Sep;32(9):1381-3
Rhabdomyosarcoma (RMS) of the lung is a very rare lesion, but the
association with cystic adenomatoid malformation (CCAM) is unlikely
to be a coincidence. Although the etiologic factors predisposing
infants and children to pulmonary neoplasms are unknown, pulmonary
developmental abnormalities may play a pathogenetic role. A case of
embryonal pulmonary RMS is described, which was discovered within a
congenital CCAM in a 22-month-old child. The hypothesis regarding
histogenesis of this neoplasm are also briefly discussed. Because of
the risk of malignant change, early removal of the congenital cystic
lesions of the lung is advisable.
Alveolar
rhabdomyosarcoma of the lung in a child.J
Pediatr Surg. 1995 Nov;30(11):1607-8.
The case of
a 22-month-old boy with alveolar rhabdomyosarcoma of the lung is
presented. Brain metastasis and recurrence of the right pulmonary
hilum and parietal pleura developed 6, 11, and 24 months
(respectively) after tumor resection. Chemotherapy and radiotherapy
were effective. Neuron-specific enolase was very helpful in
detecting metastasis and disease recurrence. Primary pulmonary
rhabdomyosarcoma can be divided into two groups: tumor in the normal
lung, and tumor in cystic lesions of the lung.
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