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Primary Malignant Melanoma of the Lung: A Case Report.World
J Surg Oncol. 2003 Nov 30;1(1):26.
BACKGROUND:
Primary melanoma of the lung is an extremely rare pathological
entity and sparsely reported in the literature. CASE PRESENTATION: A
case of primary malignant melanoma of the lung in a 41-year-old
female is reported. The clinical, radiological and histopathological
features are discussed. The initial symptom was cough, whereas the
chest radiography showed a round opacity of the right lung. The
computed tomography of the chest revealed a well-demarcated mass
lesion in the right upper lobe. Endobronchial mass causing
obstruction of the upper lobar bronchus was the bronchoscopic
finding. Patient underwent pneumonectomy. A diagnosis of melanoma
was confirmed postoperatively after the immunohistochemistry.
Primary nature of the tumour in the lung results from the
demonstration of characteristic junctional pattern of melanoma cells
beneath the bronchial epithelium on histopathology, and from
exclusion of other potential primary sites in the clinical,
paraclinical and laboratory examination. CONCLUSIONS: Primary
melanoma of the lung represents a rare pathological entity. Careful
interpretation of histopathological information in correlation with
all other findings from clinical and paraclinical studies can
establish a diagnosis. Follow-up is necessary in order to diagnose
potential dissemination or secondary sites of the disease. Due to
the small number of cases reported in the literature, there is no
experience on the management and the prognosis of the disease, but
surgical resection remains the cornerstone of the treatment.
Primary
bronchial malignant melanoma.Pathologe.
1998 Jul;19(4):299-304.
A
53-year-old man presented a melanotic lung tumor which was based in
the bronchus of the left lower lobe and closed the left main
bronchus. After laser therapy, left lobectomy with sleeve resection
was carried out. Complications after the surgery required resection
of the rest of the left lung and thoracoplasty. Based on the
histological and immunohistochemical findings, the tumor was
classified as a malignant melanoma. There was no past history of an
excision or a fulguration of a cutaneous, mucous membrane, or ocular
lesion. Examination of the skin and the eyes did not yield any
evidence of another primary tumor. We conclude that the lesion
represents a primary malignant melanoma of the respiratory tract, a
rare neoplasm of which only 21 cases have been confirmed. The
patient does not have any evidence of tumor in the relatively short
follow-up period of 10 months.
Primary
bronchial malignant melanoma. A case report.Pathologica.
1994 Oct;86(5):546-8.
A case of
primary bronchial malignant melanoma occurred in a 66 years old
woman is reported. Because of cough and hemoptysis bronchoscopic
examination was performed and and a polypoid mass was found to
occlude the right lower bronchus. Histopathologic examination showed
the presence of malignant melanoma also confirmed by immuno
reactivity with antibodies to S-100 protein and melanoma associated
monoclonal antibody HMB45. Clinical history, physical examination
and other instrumental investigations failed to find other possible
primary sites of the tumour. Primary melanoma of the lung is a very
rare condition, but our case seems to satisfy the criteria to be
considered in the little group of definite primary melanoma of the
lower respiratory tract.
Metastatic melanoma mimicking primary bronchial melanoma.
Histopathology. 1991 Jun;18(6):561-3.
Primary
malignant melanoma of the bronchus is an extremely rare neoplasm.
The criteria required to establish a bronchial origin include
junctional change and invasion of intact bronchial mucosa by
melanoma cells. A case of metastatic melanoma demonstrating such
changes is described, so casting doubt on the validity of these
criteria.
Primary
malignant melanoma of the lower respiratory tract. Report of a case
and literature review.Am
J Clin Pathol. 1990 Nov;94(5):649-55.
The authors
report a case of primary bronchial malignant melanoma, occurring in
a 34-year-old woman presenting with persistent cough. At
bronchoscopic examination, a polypoid mass was found to occlude the
left mainstem bronchus. Biopsies showed a malignant epithelioid
tumor resembling an atypical carcinoid. Histochemistry, electron
microscopic study, and immunohistochemistry confirmed the diagnosis
of melanoma. Physical examination and additional clinical history to
exclude other possible primary sites were negative. The patient
underwent thoracotomy with left pneumonectomy. Nineteen months after
resection she was found to have a histologically similar tumor
involving her left adrenal gland. Review of the literature shows
that melanoma of the lower respiratory tract has been reported only
in adults and has a tendency to present as a central polypoid growth
that may be responsive to surgical resection.
Bronchial
malignant melanoma.J
Surg Oncol. 1980;15(3):243-8.
We describe
a case of malignant melanoma presenting initially as an
endobronchial lesion located in the left main bronchus causing total
atelectasis. This resolved with radiation therapy. Widespread
metastases developed shortly thereafter. The differential diagnosis
of primary and metastatic bronchial malignant melanoma is discussed.
Other isolated case reports are reviewed.
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