| Two
cases of primary pulmonary osteosarcoma. Intern
Med. 2005 Jun;44(6):632-7
Two cases of
primary pulmonary osteosarcoma are presented. In both cases, chest
computed tomography revealed a calcified pulmonary mass and
technetium-99m methylene diphosphonate bone scintigraphy showed
intense uptake in the pulmonary mass. Primary pulmonary osteosarcoma
was suspected on the basis of these radiographic findings. Microscopic
examination of tumor specimens obtained by needle biopsy revealed
histologic features of osteosarcoma, and this diagnosis was confirmed
by postmortem examination of a second specimen in each case.
Radiographic and histopathological findings enabled us to diagnose
primary pulmonary osteosarcoma, which is one of the rarest types of
cancer.
Primary osteosarcoma of the lung: report of a case.
Surg Today. 2004;34(2) :150-2.
Osteosarcoma of
the lung without an extrathoracic primary tumor is extremely rare,
with only eight cases documented in the literature, to the best of our
knowledge. We report a case of primary osteosarcoma of the lung found
in an asymptomatic 74-year-old woman. Computed tomography showed a
heterogeneous mass beside the aortic arch, and the patient underwent a
left upper lobectomy. The pathology results confirmed a diagnosis of
primary osteosarcoma.
Primary
pulmonary osteogenic sarcoma.
Skeletal Radiol. 2000 May;29
(5):283-5.
A 56-year-old
man initially presented to his family physician with tingling in the
fingertips of his left hand. A chest radiograph revealed a left upper
lobe mass. Local resection found a soft tissue osteogenic sarcoma.
This is a report of a rare case of primary pulmonary osteogenic
sarcoma.
Primary
osteosarcoma of the lung. Report of two cases and review of the
literature.
J Thorac Cardiovasc Surg. 1990 Dec;100(6):867-73.
Two cases of
primary osteosarcoma of the lung are presented. In one case, the
radiologic, clinical, and cytologic findings led to a preoperative
diagnosis of undifferentiated carcinoma of the lung. In the second
case, a lung nodule was discovered during postchemotherapy follow-up
in a patient with lymphoma. Fine needle aspiration in the second case
showed lymphoma, and further chemotherapy was instituted; however,
persistent growth of the nodule prompted a resection. Microscopic
examination of the resected tumors in both cases revealed histologic
features of high-grade osteosarcoma. Flow cytometric analyses of the
primary tumors showed abnormal hyperdiploid deoxyribonucleic acid
populations in accordance with those seen in high-grade malignant
neoplasms. Immunohistochemical studies supported a mesenchymal origin
for these tumors. These tumors shared clinical features with other
reported cases of primary osteosarcoma of the lung such as large size
at diagnosis, occurrence in older individuals, and aggressive
behavior.
Pulmonary
metastasectomy for osteosarcomas and soft tissue sarcomas.
Gan To Kagaku Ryoho. 2004 Sep;31(9):1319-23.
To evaluate the
efficacy of aggressive pulmonary metastasectomy for treating
osteosarcomas and soft tissue sarcomas, we reviewed 105 cases treated
in our hospital between 1990 and 2002. There were 57 males and 48
females, 44 osteosarcomas (OS), 21 synovial sarcomas (Syno), 16
malignant fibrous histiocytomas (MFH), 4 leiomyosarcomas (Leio), 4
alveolar soft part sarcomas (ASPS) and 16 others (including
chondrosarcoma and liposarcoma). A total of 904 metastases were
resected (8.6(0-49)/patients) and 244 thoracotomies (2.3/patients)
were performed. Mean number of initial metastasectomies was 3.7
(0-26), disease-free interval (DFI) was 13. 8 months (0-96), and mean
diameter of maximum resected metastases for one patient was 20.4
(5-90) mm. Five-and 10-year survival rates of all cases were 44.9% and
32.0% respectively. Those of OS were 45.8% and 38.5%, and those of
soft tissue sarcomas were 44.2% and 25.5%, respectively. The highest
5-and 10-year survival rates among soft tissue sarcomas was attained
in ASPS and Leio (75%), and others (51.6% and 38.7%), followed by Syno
(42.9% and 12.4%). Long-term survival was not attained in MFH (30.9%:
5 years). Analysis of histological types of the tumors and numbers of
resected pulmonary metastases showed that the largest number of
metastases were resected in ASPS (16/case) and Syno (13.8/case),
followed by OS (9.0/case). MFH had the largest (27.1 mm) mean diameter
of maximum resected metastases, followed by Leio (27.0 mm). Analysis
of prognostic factors indicated that curativity was the most important
prognostic factor: curative cases 42.2% (10-year survival) vs
noncurative cases 4.2% (6-year survival). Number of resected
metastases and mean diameter of maximum tumor size also affected the
patient survival.
Primary osteosarcoma of the lung. A reappraisal
following immuno histologic study.
Arch
Pathol Lab Med. 1989 Oct;113(10):1147-50.
Five neoplasms
were initially believed to represent primary osteosarcomas of the
lung. Of the five cases, two were reinterpreted as carcino-sarcomas
based on the identification of epithelial elements on further
histologic sectioning and immunohistologic study in one and on
immunohistologic study alone in the second. The differential diagnosis
of carcinosarcoma should be considered for any lesion believed to
represent a primary sarcoma of the lung, and in some cases
carcinomatous elements may only be demonstrable by immunohistologic
means.
Primary chondrosarcoma of the lung. A clinicopathologic study.Cancer.
1993 Jul 1;72(1):69-74.
BACKGROUND.
Primary pulmonary chondrosarcoma is a rare neoplasm. A 73-year-old
Japanese man had chondrosarcoma in the right lung. The tumor was
considered to be of pulmonary origin because of the absence of
extrapulmonary primary lesions for 2 years after lung resection.
METHODS. The histologic sections were stained with hematoxylin and
eosin, conventional special staining, and immunohistochemical
staining. The authors discussed the differential diagnosis and growth
pattern, in addition to the histopathologic findings in the tumor
cells. In a review of the literature, the authors compared the
characteristics between the major bronchus (MB) and lung types.
RESULTS. Histopathologically, the tumor cells showed atypical
cartilaginous differentiation without osteoid formation, benign or
malignant-appearing epithelium, or sarcomatous components other than
chondrosarcoma. The tumor showed expansive proliferation, invasion
through the alveolar spaces, massive proliferation along the bronchial
lumen, significant invasion into small vessels, and extrathoracic
metastases. The review of the literature showed that the clinical
period ending with surgical treatment was longer in the lung tumors
than in the MB tumors. CONCLUSIONS. Although MB tumors were reported
to be discovered early, the invasion to major arteries or trachea
often led to inoperability; however, lung tumors were considered to be
resectable until they grew very large, even though the clinical period
from onset to surgical treatment was longer in this type. Recent
advancements in diagnostic and surgical techniques are expected to
promote early discovery and improve prognosis whether the tumor occurs
in the MB or lung.
Primary chondrosarcoma of lung: case report and review
of literature.
Indian J
Pathol Microbiol. 2006 Oct;49(4):570-3.
A case of primary
chondrosarcoma of the left lung in 50 year-old man is presented. The
tumor was diagnosed as primary chondrosarcoma of the lung after
exclusion of any primary lesion elsewhere. Histologically, tumor
consisted of predominantly chondromatous lesion. Immunohistochemistry
showed that tumor cells positive for S-100 protein and vimentin, and
negative for epithelial markers. On the basis of clinical,
histological and immunohistochemical studies, the tumor was diagnosed
as a primary chondrosarcoma of the lung.
Primary mesenchymal chondrosarcoma of the lung.
Ann Thorac
Surg. 2002 Jun;73(6):1960-2.
Mesenchymal
chondrosarcoma has been well documented in the somatic soft tissue and
bone. It is a rare subtype of chondrosarcoma characterized by the
presence of islands of chondroid or by less osteoid tissue enmeshed
within dense sheets of primitive small blue mesenchymal cells with
hemangiopericytoma-like vessels, or by both. The vast majority of
previously published pulmonary mesenchymal chondrosarcoma was
metastatic. To the best of our knowledge, only one case of primary
pulmonary mesenchymal chondrosarcoma has been described in the
literature. Herein, we report the second case of primary mesenchymal
chondrosarcoma of the lung and emphasize that biopsy may yield only
nonspecific small blue cells, whereas a detailed evaluation of the
resected specimen allows definite diagnosis of this rare lung tumor.
Primary chondrosarcoma of the lung recognized as a long-standing
solitary nodule prior to resection.Jpn
J Thorac Cardiovasc Surg. 2005
Feb;53(2):106-8.
As the use of
computed tomography (CT) increases, incidental lung nodules have
become a clinical issue that is being addressed more than before. We
detected a solitary lung nodule which was smooth-margined,
round-shaped, 11 mm in size. Follow-up for 18 months after initial
detection by chest CT did not show any interval change. To make a
definitive diagnosis, video-assisted thoracic surgery was performed
and the lesion was diagnosed as myxoid chondrosarcoma. In the 6-year
postoperative follow-up, annual chest CT and bone scintigram did not
reveal any abnormality, which excludes the possibility of a latent
primary site other than the lung. Therefore, we considered the present
case being of pulmonary origin. Accordingly, even though the lesion
appeared unremarkable, surgical resection of solitary lung nodule
should not be discouraged.
Primary chondrosarcoma of the lung.Zhonghua
Zhong Liu Za Zhi. 1992 Nov;14(6):447-8.
Five cases of
primary chondrosarcoma, a rare tumor of the lung, are reported. The
diagnosis should be made by pathology. Some conditions should be ruled
out: 1. tumor from the chest wall, 2. chondrosarcoma of bone
discovered after operation, 3. ovarian teratoma found prior to
operation, 4. patient with history of hamartoma of the lung, and 5.
atypical pathology. Pathologic subtyping is not prognostic. The main
cause of death was intralobar spread. It never gives rise to
extrathoracic metastasis and should be treated by surgery.
Primary
mesenchymal chondrosarcoma of the lung. A case report with
immunohistochemical and ultrastructural studies.Acta
Pathol Jpn. 1992 May;42(5):364-71.
A case of primary
pulmonary mesenchymal chondrosarcoma is reported. The tumor occurred
first in the lower lobe of the right lung of a Japanese female aged
45. Three years after the first operation it metastasized to the upper
lobe of the left lung. The tumors were highly cellular and composed of
undifferentiated mesenchymal cells and interspersed islands of
well-differentiated cartilaginous tissue. Immunohistochemistry failed
to detect S-100 and vimentin in the undifferentiated cells. In
contrast, Leu-7 and blood coagulation factor XIIIa were positive in
these cells. Electron microscopically, undifferentiated mesenchymal
cells had narrow cytoplasm with sparsity of organelles, but no
intermediate-sized filaments were detected. In the transitional areas
between undifferentiated cells and cartilaginous components, thin
intracytoplasmic filaments were sometimes observed in the tumor cells.
The differentiation toward cartilaginous cells of undifferentiated
mesenchymal cells was suggested by immunohistochemistry and electron
microscopy. This is the first case of mesenchymal chondrosarcoma
occurring in the lung with long-term follow-up.
Fine-needle aspiration cytology of an unusual primary lung tumor,
chondrosarcoma: case report.Diagn
Cytopathol. 1991;7(4):423-6.
A case of primary
chondrosarcoma of the lung diagnosed by fine-needle aspiration biopsy
(FNAB) cytology in a 78-yr-old male is presented. A mass detected on
chest x-ray and defined by CT scan was subjected to a preoperative
percutaneous fine-needle aspiration under fluoroscopic guidance. The
distinctive cytologic features of pleomorphic cells nestled in lacunae
surrounded by a chondromyxoid background resulted in a diagnosis of
chondrosarcoma. The left upper lobectomy specimen confirmed the FNAB
diagnosis and identified the tumor as arising from the left upper lobe
bronchus.
Primary chondrosarcoma of the lung--a case report with immuno
histochemical study.
Jpn J Med.
1990 Nov-Dec;29(6):616-9.
A case of primary
chondrosarcoma of the lung is presented. The tumor, located in the
medial segment of the right lower lobe, was successfully resected
surgically. Clinical survey did not reveal any primary lesion
elsewhere. The tumor consisted of myxomatous, chondromatous, and
fibrous lesions. Immunohistochemical study revealed that tumor cells
were positive for S-100 protein and vimentin, and negative for other
antisera which characterize epithelial tumors. With these clinical,
histological, and immunohistochemical studies we diagnosed the tumor
as a primary chondrosarcoma of the lung.
Primary
chondrosarcoma of the left inferior lobar bronchus.Respiration.
1989;56(3-4):241-4.
A primary
chondrosarcoma arising in the left inferior lobar bronchus is
described in a 67-year-old man. The symptoms upon admittance were
dyspena, cough with purulent sputum and weight loss. The tumor was
removed by pneumonectomy. Eight months later the patient died of
massive mediastinal lymph node involvement. While tracheobronchially
located primary pulmonary chondrosarcoma tends to remain localized,
the peripheral variety tends toward mediastinal lymph node involvement
and thoracic metastasis. The treatment of choice is resection in a
radical manner, whenever possible.
Primary chondrosarcoma of the lung. A report of two cases.Clin
Oncol. 1984 Sep;10(3):273-9.
This report
describes two cases of primary chondrosarcoma arising in the lung. In
both cases, the treatment was palliative due to unresectable primary
tumours. One patient's tumour appears to have originated in a
persistent hamartoma; the other, from lung parenchyma. Primary
chondrosarcoma of the lung tends to remain localized. Wide local
excision is the treatment of choice when possible. Palliation can be
accomplished with radiation and/or systemic chemotherapy.
Chondrosarcoma of
the bronchus.Chest.
1983 Aug;84(2):224-6.
A primary
chondrosarcoma of the right main bronchus was removed by pneumonectomy
in a 74-year-old woman. The presenting symptoms were dyspnea and cough
with a lung mass evident for 18 months. She is well and free of tumor
16 months later. Only eight established cases of primary
chondrosarcoma arising from the lung, and four originating from the
tracheobronchial tree have been previously described. The long
preoperative history and the outcome so far confirm the relatively
less aggressive character of the tracheobronchial as compared to the
lung subdivision of primary pulmonary chondrosarcoma.
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