Pancreatic Pathology Online

Pathology of Pancreatic Agenesis 

"Absence of the parts of adult gland derived from the dorsal pancreas, namely, the body and tail."

Dr Sampurna Roy MD        

 

Total agenesis of the pancreas is extremely rare. It is often associated with other severe congenital malformations and is  usually incompatible with life

Hypoplasia (partial agenesis) results from the absence of  the ventral or dorsal pancreatic anlage.

In complete dorsal agenesis, the anterior head, neck, body and tail of the pancreas, the duct of Santorini and the minor papilla are absent.

In partial dorsal agenesis, a variable amount of pancreatic tissue is absent but a remnant of the duct of Santorini and the minor papilla are present.

Patients with dorsal pancreatic agenesis have an increased risk of diabetes mellitus because most of the islet cells are located in the distal pancreas.

 

Further reading:

Congenital variants and anomalies of the pancreas and pancreatic duct: imaging by magnetic resonance cholangiopancreaticography and multidetector computed tomography.

Polysplenia syndrome with congenital agenesis of dorsal pancreas presenting as acute pancreatitis and the role of endoscopic ultrasonography in its diagnosis.

Morphologic classification of congenital short pancreas on multidetector computed tomography.

MR in complete dorsal pancreatic agenesis: Case report and review of literature.

A novel mutation in GATA6 causes pancreatic agenesis.

Dorsal pancreas agenesis and ductal adenocarcinoma: surgical implications of an extremely rare association.

Polysplenia syndrome with agenesis of the dorsal pancreas and preduodenal portal vein presenting with obstructive jaundice--a case report and literature review.

 

 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)


 

 

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