Pancreatic Pathology Online

Pathology of Undifferentiated (Anaplastic) Carcinoma of the Pancreas

Dr Sampurna Roy MD                  


Syn: Anaplastic ; Pleomorphic Large Cell ; Pleomorphic Giant Cell; Sarcomatoid Carcinoma.

Undifferentiated (anaplastic) tumour is a rare, aggressive tumour which constitute about 2-7% of exocrine pancreatic cancers.

Age and sex:  The tumours have similar age and sex distribution like ductal adenocarcinoma but are clinically more aggressive.

Visit: Exocrine Pancreatic Tumours

Gross features: Grossly, they are large and soft with prominent hemorrhage, necrosis and cystic changes.

Microscopic features:  Microscopically, the tumour consists of large mononuclear pleomorphic cells and bizarre multinucleated giant cells, with scanty fibrous stroma.

Mitoses are frequent.

Image of Undifferentiated Carcinoma of Pancreas

Spread: There is extensive perineural, lymphatic and vascular invasion.

Visit: Undifferentiated Carcinoma with Osteoclast-like Giant Cell


Further reading:

Undifferentiated carcinoma of pancreas: a rare entity with aggressive behavior and possible genetic link.

Splenic infarction.A rare presentation of anaplastic pancreatic carcinoma and a review of the literature.

Anaplastic pancreatic carcinoma.A case report and review of literature.

A clinicopathologic and immunohistochemical study of 35 anaplastic carcinomas of the pancreas with a review of the literature

Phenotypical characteristics of undifferentiated carcinoma of the pancreas: a comparison with pancreatic ductal adenocarcinoma and relevance of E-cadherin,  alpha catenin and beta catenin expression.




Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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