Pancreatic Pathology Online

Pathology of Pancreatic Schwannoma

Dr Sampurna Roy MD              


Schwannoma of the pancreas is a rare neoplasm.

Visit: Schwannoma (neurilemmoma) and variants ;  

It generally affects older adults (average age, 60 yr).

The sex incidence is equal.

These tumours vary considerably in size and approximately two-thirds are partially cystic, which can cause clinical confusion with epithelial neoplasms.

Cystic schwannoma occurring in the pancreas should be considered in the differential diagnoses for patients presenting with pancreatic cystic lesions.


Histologically, they are typical schwannomas, with Antoni A and Antoni B areas, and they do not cause undue  diagnostic problems once adequate tissue is examined histologically.

Immunostaining show that the tumour cells are strongly  and diffusely positive for S-100 protein, vimentin, and CD56, and negative for cytokeratin AE1/AE3, desmin, smooth muscle myosin specific, CD34, and CD117, which support the diagnosis of schwannoma.


Further reading:

Schwannomatosis presenting as pancreatic and submandibular gland schwannoma.

Pancreatic schwannoma: A case report and review of literature.

Pancreatic schwannoma: Case report and an updated 30-year review of the literature yielding 47 cases.

Role of intraoperative ultrasonography for pancreatic schwannoma.

Pancreatic benign schwannoma: combined with hemorrhage in an internal cyst.

Pancreatic schwannoma: a case report and literature review with special reference to imaging features.

Pancreatic schwannoma: literature review.

Pancreatic schwannoma in a 32-year-old woman mimicking a solid-pseudopapillary neoplasm.




Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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