Pancreatic Pathology Online

Pathology of Non-Neoplastic Pancreatic Cysts

Dr Sampurna Roy MD              July 2016



Congenital cysts ( True cysts ) of the Pancreas:

Congenital cysts ( True cysts ) are defined as anomalous development of the pancreatic ducts.

Although their mode of origin is not understood, it is postulated that cysts are caused by the failure of embryonic ducts to regress as they are replaced by more permanent ones.

Remnants of persistent ducts are presumed to become obstructed and form cysts that fill with fluid.

Congenital cysts can be single or multiple and range in size from a few millimeters to large cysts that may fill the upper abdomen.

Such cysts are lined by cuboidal-to-flat epithelium and contain fluid with both amylase and proteolytic enzyme activity.

Cysts frequently coexist with kidney and liver cysts in congenital polycystic disease.

In von Hippel-Lindau disease, pancreatic cysts and angiomas of the central nervous system occur.

Pseudocysts of Pancreas

Pseudocyts are localized collections of fluid representing sequestered pancreatic secretions, almost always arising after bouts of acute or chronic pancreatitis. 

They do not possess an epithelial lining but instead are  lined by fibrosed inflammatory tissue.

Pseudocyts are usually unilocular.

Symptoms include abdominal pain. They may become infected or hemorrhagic.

Acute pancreatitis is a serious complication of organophosphate poisoning. Pancreatic pseudocyst may develop after complication of organophosphate-induced acute pancreatitis.

Non-neoplastic cystic and cystic-like lesions of the pancreas are rare causes of pancreatic cystic lesions that are generally benign and do not require surgery when asymptomatic.


Further reading:

Pancreatic pseudocyst. Case report and literature review.

Non-neoplastic cystic and cystic-like lesions of the pancreas: may mimic pancreatic cystic neoplasms.

Approach to cystic lesions of the pancreas.

Congenital pancreatic cyst: diagnosis and management.

Pancreatic pseudocysts in chronic pancreatitis. Differential diagnosis and therapy.

The modern approach to endoscopic drainage of pancreatic pseudocysts.

Cystic lesions of the pancreas.

Congenital pancreatic cyst arising from occlusion of the pancreatic duct.

Pancreatic pseudocyst development due to organo phosphate poisoning.

Pancreatic pseudocyst after acute organophosphate poisoning.

Congenital true pancreatic cyst: a rare case.

Congenital true pancreatic cyst in pediatric age: case report.




Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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