Pancreatic Pathology Online

Pathology of Mucinous Non Cystic and Signet Ring Cell Carcinoma of the Pancreas

Dr Sampurna Roy MD         


Syn: Colloid or Gelatinous Carcinoma

Mucinous Non Cystic (colloid) carcinoma of the pancreas is an uncommon variant of ductal adenocarcinoma resembling adenocarcinoma in terms of sex distribution,  median age, and location within the pancreas.

Grossly, it is a soft and gelatinous tumour (due to abundant mucin production).

Microscopically, the tumour is composed of pools of mucus containing clumps of neoplastic glandular epithelium.

 Pools of mucus containing clumps of neoplastic glandular epithelium.

Small groups of signet-ring cells are seen freely floating in the mucus.

Groups of signet-ring cells are seen freely floating in the mucus.

Signet-ring cell carcinomas (at least 50%) contain intra-cytoplasmic mucin.

It diffusely infiltrate the pancreas and the prognosis is poor.


Further reading:

WHO-classification 2000: exocrine pancreatic tumors.

Colloid (mucinous noncystic) carcinoma of the pancreas.

The spectrum of mucin-producing adenocarcinoma of the pancreas.

Pancreatic tumors with cystic dilatation of the ducts: intraductal papillary mucinous neoplasms and intraductal oncocytic papillary neoplasms.

Pathogenesis of colloid (pure mucinous) carcinoma...

Rare primary signet ring carcinoma of the pancreas.

Signet ring cell carcinoma of the pancreas: a case report.

Signet-ring mucinous adenocarcinoma of the pancreas.




Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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