Pancreatic Pathology Online
Pathology of Primary Pancreatic Lymphoma
neoplasms of the pancreas are most often adenocarcinoma.
Non-Hodgkin's lymphoma (NHL) involving the pancreas is less common but well documented.
Primary pancreatic Non-Hodgkin lymphoma predominantly involving the pancreas is a rare tumour and accounts for less than 0.7% of all pancreatic malignancies and 1% of extranodal lymphomas.
The expression "pancreatic lymphoma" has been used to describe both primary lymphoid neoplasms originating in the pancreatic parenchyma and tumours invading from a peri-pancreatic lymphadenopathy.
The majority of patients with pancreatic cancer,whether it is adenocarcinoma or lymphoma, present with a mass in the head of the gland.
Pancreatic lymphoma is often described as a large homogeneous mass with extra-pancreatic extension, with or without associated lymphadenopathy.
Less common presentations are masses in the body or tail, or more rarely diffuse involvement of the pancreas.
Percutaneous fine-needle aspiration (FNA) of the pancreas requires experienced cytopathologists as well as advanced immuno-histochemical assays to obtain a final diagnosis on a small amount of tissue.
Histopathological examination is usually mandatory to obtain a definitive diagnosis since symptoms and radiological features are quite similar to those of other pancreatic masses.
Follicular lymphoma is a rare subtype of primary pancreatic lymphoma.
In case of primary pancreatic lymphoma, surgery and adjuvant chemotherapy or radiotherapy can produce fairly good outcomes.
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