Pancreatic Pathology Online
Pathology of Lymphoepithelial Cyst of the Pancreas
cyst is a rare, benign lesion
described in 1985 by Luchtrath and Schriefers.
pancreatic cyst with features of a so-called branchiogenic cyst].
This lesion should be taken into consideration when evaluating a cystic lesion of the pancreas because of different therapeutic approach in each case.
The pathogenesis of lymphoepithelial cysts is unclear.
Lymphoepithelial cysts are seen predominantly in men, (Male/Female : 4/1) and in adults (mean age, 56, and range, 35 to 74 years).
They may occur at any site of the organ (head, body, or tail).
Lymphoepithelial cysts are well-delineated cysts that may be multilocular (60%) or unilocular (40%). The size of the lesion may range from 1 to more than 15 cms.
Microscopically, they are characterized by stratified squamous epithelium surrounded by a band of mature lymphoid tissue with intervening well-formed germinal centers.
In some areas, the lining epithelium display more cuboidal, flattened, or transitional appearance.
Mucinous goblet-like cells are seen in some cases.
Solid lymphoepithelial clusters are seldom seen.
Clinical diseases that are known to be associated with their counterparts in the salivary glands such as Sjogren disease or human immunodeficiency virus have not been documented for the lymphoepithelial cysts of the pancreas.
Cytological and histological analysis of fine needle aspiration material is of diagnostic interest and can avoid surgical resection when patients are symptom-free.
- Epidermoid cyst of the pancreas - These are located almost exclusively in the tail of the pancreas, in the fourth decade of life. In some cases, the cyst lining may be partly mucinous.
- Dermoid cysts of the pancreas - Occur in a younger age group, in contrast with lymphoepithelial cyst , there is no gender predominance.Squamous-lined cysts of the pancreas: lymphoepithelial cysts, dermoid cysts (teratomas), and accessory-splenic epidermoid cysts.
Mucinous epithelium, respiratory-type mucosa and sebaceous units are more readily identifiable in dermoid cysts, and they may contain hair.
Subepithelial lymphoid tissue is not a feature.
They are sometimes complicated by suppurative infections.
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