Pancreatic Pathology Online

Pathology of  Osteoclast - like Giant Cell Tumour of the Pancreas

Dr Sampurna Roy MD            

 

Undifferentiated carcinoma with osteoclast-like giant cells is a rare neoplasm of exocrine pancreas.

Exocrine Pancreatic Tumours.

The association of these tumors with conventional adenocarcinoma or mucinous cystic neoplasms, the histologic features, and the immunohistochemical profile supports an epithelial phenotype for the mononuclear cells and a reactive histiocytic lineage for the nonneoplastic osteoclast-like giant cells.

This very rare neoplasm resembles giant cell tumor of bone.

An epithelial origin is now established and this tumor has been recently considered as a variant of ductal adenocarcinoma of the pancreas in the last WHO  histological classification.

The diagnosis requires both morphology and immunohistochemistry.

These tumours are characterized by a dual population of mononuclear pleomorphic spindle and polygonal cells and osteoclast-like multinucleated giant cells with high mitotic activity.

Glandular structures and epithelial nests may be present.

Electron microscopy and immunohistochemical results:

(i) Positive immunostaining for cytokeratin of the mononuclear pleomorphic cells favours an epithelial origin.

(ii) Positive vimentin in the spindle cell with negative keratin staining suggest a mesenchymal origin.

(iii) Osteoclast-like cells stain for vimentin and leukocyte common antigen (CD45).

Overall view favour "a primary epithelial phenotype".

Prognosis: These neoplasms, which are better classified as undifferentiated carcinomas, follow an aggressive clinical  course and most patients die of disease within 1 year.

 

Further reading:

Long-term survivor of a resected undifferentiated pancreatic carcinoma with osteoclast-like giant cells who underwent a second curative resection: A case report and review of the literature.

Osteoclastic giant cell tumor of the pancreas

Huge undifferentiated carcinoma of the pancreas with osteoclast-like giant cells.

Effective use of gemcitabine in the treatment of undifferentiated carcinoma with osteoclast-like giant cells of the pancreas with portal vein tumor thrombus.

Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells.

A male case of an undifferentiated carcinoma with osteoclast-like giant cells originating in an indeterminate mucin-producing cystic neoplasm of the pancreas. A case report and review of the literature.

Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas diagnosed by endoscopic ultrasonography-guided fine-needle aspiration.

Pathomorphologic study of undifferentiated carcinoma in seven cases: relationship between tumor and pancreatic duct epithelium.

Undifferentiated pancreatic carcinoma with osteoclast-like giant cells: report of a case with osteochondroid differentiation.

Endoscopic ultrasound-guided fine-needle aspiration of undifferentiated carcinoma with osteoclast-like giant cells of the pancreas: a report of 2 cases with literature review.

Rapidly progressing cyst of the pancreas as a manifestation of an undifferentiated pancreatic carcinoma with osteoclastic giant cells.

Huge pseudocyst of the pancreas caused by poorly differentiated invasive ductal adenocarcinoma with osteoclast-like giant cells: report of a case.

Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas

Non-differentiated carcinoma with osteoclast-like giant cells of the pancreas: a case report.

Adenosquamous carcinoma of the pancreas with an acantholytic pattern together with osteoclast-like and pleomorphic giant cells.

A case of osteoclast-like giant cell tumor of the pancreas with ductal adenocarcinoma: histopathological, immunohistochemical, ultrastructural and molecular biological studies.

Endoscopic ultrasound-guided fine-needle aspiration of undifferentiated carcinoma with osteoclast-like giant cells of the pancreas: a report of 2 cases with literature review.

Rapidly progressing cyst of the pancreas as a manifestation of an undifferentiated pancreatic carcinoma with osteoclastic giant cells.

 

 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)


 

 

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