Pancreatic Pathology Online

Pathology of Dermoid Cyst of the Pancreas

Dr Sampurna Roy MD             


Dermoid cyst, also called cystic teratoma of the pancreas is a benign, well-differentiated, extremely rare germ cell neoplasm.

Dermoid cyst of the pancreas is a true cyst and consists of stratified squamous epithelium and underlying connective tissue.

Clinical presentation: It is non specific and include abdominal pain, back pain, nausea, vomiting, anorexia, weight loss, fatigue and fever.

Gross features:  Cyst contains differentiated tissues from one or more germ cell layers, usually ectodermal.

The cyst content appears  "cheesy"  or "caseous", with keratinaceous and sebaceous secretions.

Rarely the  cyst content may be clear and serous.

Microscopic features: The cyst is lined by stratified squamous epithelium.


Mucinous epithelium, respiratory-type mucosa, sebaceous units and hair follicles are readily identifiable in dermoid cysts.

The serum markers, such as CEA and CA19-9, are usually significantly lower in dermoid cysts rather than in other  pancreatic cystic neoplasms.

Differential diagnosis : Pancreatic cysts lined by squamous epithelium, e.g. lymphoepithelial cyst  and epidermoid cyst.  

Visit: Cystic Tumours of the Pancreas

Primary neoplastic cysts of the pancreas (e.g. mucinous cystic tumours , intraductal papillary mucinous tumour  and intraductal oncocytic papillary neoplasms). Rare cystic forms of solid pancreatic tumours ( solid pseudopapillary tumour , ductal adenocarcinomas , cystic islet cell tumours , and acinar cell cystadenocarcinoma ).

Visit:  Exocrine Pancreatic Tumours. ; Non-Neoplastic Pancreatic Cysts including Congenital and Pseudocysts .


Further reading:

Squamous-lined cysts of the pancreas: lymphoepithelial cysts, dermoid cysts (teratomas), and accessory-splenic epidermoid cysts.

Dermoid cyst of the pancreas: presentation and management.

Cystic teratoma of the pancreas: presentation, evaluation and management.

Dermoid cyst of the pancreas: a rare cystic neoplasm.

Fine-needle aspiration of dermoid cyst of the pancreas: a case report.

Cystic teratoma of the pancreas.

Dermoid cyst of the pancreas. Case report and review of the literature.




Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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