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Dermoid cyst, also called cystic teratoma of the pancreas is a benign, well-differentiated, extremely rare germ cell neoplasm. Dermoid cyst of the pancreas is a true cyst and consists of stratified squamous epithelium and underlying connective tissue.

Clinical presentation: It is non specific and include abdominal pain, back pain, nausea, vomiting, anorexia, weight loss, fatigue and fever.

Gross features:  Cyst contains differentiated tissues from one or more germ cell layers, usually ectodermal. The cyst content appears  "cheesy"  or "caseous", with keratinaceous and sebaceous secretions. Rarely the  cyst content may be clear and serous.

Microscopic features: The cyst is lined by stratified squamous epithelium. Mucinous epithelium, respiratory-type mucosa, sebaceous units and hair follicles are readily identifiable in dermoid cysts.

The serum markers, such as CEA and CA19-9, are usually significantly lower in dermoid cysts rather than in other  pancreatic cystic neoplasms.

Differential diagnosis : Pancreatic cysts lined by squamous epithelium, e.g. lymphoepithelial cyst  and epidermoid cyst.  

Visit: Cystic Tumours of the Pancreas

Primary neoplastic cysts of the pancreas (e.g. mucinous cystic tumours , intraductal papillary mucinous tumour  and intraductal oncocytic papillary neoplasms). Rare cystic forms of solid pancreatic tumours ( solid pseudopapillary tumour , ductal adenocarcinomas , cystic islet cell tumours ,and acinar cell cystadenocarcinoma ).

Squamous-lined cysts of the pancreas: lymphoepithelial cysts, dermoid cysts (teratomas), and accessory-splenic epidermoid cysts.Semin Diagn Pathol. 2000 Feb;17(1):56-65.

In the pancreas, 3 types of morphologically similar lesions may present as "squamous cysts": Lymphoepithelial cysts, dermoid cysts (monodermal teratomas), and epidermoid cysts in intrapancreatic accessory spleen. Lymphoepithelial cysts (LECs) are seen predominantly in men (M/F: 4/1) and in adulthood (mean age, 56, and range, 35 to 74 years). They may occur at any site of the organ (head, body, or tail). LECs are well-delineated cysts that may be multilocular (60%) or unilocular (40%), and they are characterized microscopically by stratified squamous epithelium surrounded by a band of mature lymphoid tissue with intervening well-formed germinal centers. Solid lymphoepithelial clusters are seldom seen. The pathogenesis of LECs is unclear; clinical diseases that are known to be associated with their counterparts in the salivary glands such as Sjogren disease or human immunodeficiency virus have not been documented for the LECs of the pancreas. The second type of squamous-lined cyst in the pancreas is the epidermoid cyst arising in intrapancreatic accessory spleen. These are located almost exclusively in the tail of the pancreas, in the fourth decade of life (mean age = 38). Their mean size is 4.5 cm (range, 2.3 to 6.5). In some cases, the cyst lining may be partly mucinous. Dermoid cysts of the pancreas are also rare. The cases that appear to be true dermoid cysts occur in a younger age group (mean age, 23, range, 2 to 53 years), and in contrast with LEC, there is no gender predominance. Mucinous epithelium, respiratory-type mucosa and sebaceous units are more readily identifiable in dermoid cysts, and they may contain hair. Subepithelial lymphoid tissue is not a feature. They are sometimes complicated by suppurative infections. The importance of these lesions is in their distinction from other cystic neoplasms, especially mucinous cystic tumors.

                   

Dermoid cyst of the pancreas: presentation and management. World J Surg Oncol. 2007 Aug 3;5:85.

BACKGROUND: Dermoid cyst of the pancreas is a benign, well-differentiated, extremely rare germ cell neoplasm. Published data indicate that differential diagnosis of cystic lesions of the pancreas is challenging and although ultrasonography, computed tomography and magnetic resonance may be useful, radiological findings are often inconclusive and the diagnosis is intraoperative. We report a case of a dermoid cyst of the tail of the pancreas intraoperatively diagnosed and successfully treated with left pancreatectomy. Further, characteristics, preoperative detection and differential diagnosis of this rare pathology are also discussed. CASE PRESENTATION: This report documents the findings of a 64-year-old male presenting with a well defined echogenic pancreatic mass on ultrasonography. Computerized Tomography (CT) showed a 5 cm cystic tumor arising from pancreatic tail and Magnetic Resonance Imaging (MRI) suggested a tumor extension to the middle side of the stomach without defined margins. A left pancreatectomy was performed. On surgical specimen, histological evaluation revealed a dermoid cyst of the tail of the pancreas measuring 8.5 x 3.0 cm. CONCLUSION: Given the benign nature of the dermoid cyst, surgical resection most likely represents the definitive treatment and cure. In addition, resection is indicated in consideration of the difficulty in diagnosing dermoid cyst preoperatively. However, endoscopic ultrasound and fine needle aspiration cytology have recently been shown to be effective, safe, reliable and cost-saving preoperative diagnostic tools. Therefore, until more cases of dermoid cyst are identified to further elucidate its natural history and improve the reliability of the preoperative diagnostic tools, surgical resection should be considered the standard therapy in order to exclude malignancy.

Cystic teratoma of the pancreas: presentation, evaluation and management.JOP. 2006 Nov 10;7(6):643-6.

CONTEXT: Congenital cystic lesions of the pancreas are rare findings. Furthermore, a dermoid cyst of the pancreas is exceptionally uncommon. A review of the world literature shows 18 documented cases. The pre-operative evaluation of this lesion is rather questionable, with definitive diagnosis taking place intra-operatively. CASE REPORT: A 52-year-old male with a symptomatic, 3-cm cystic-type mass in the pancreas. CONCLUSIONS: From our case presentation and review of the world literature, we hope to establish an increased awareness in the diagnostic evaluation of these patients.

Dermoid cyst of the pancreas: a rare cystic neoplasm. Hepato gastroenterology. 1998 Sep-Oct;45(23):1874-6.

Dermoid cysts of the pancreas, also called cystic teratomas, are a rare entity and are included in the group of neoplasms with a germ cell origin. Only twelve cases have been described in the world literature. The symptomatology is due to tumor compression of the neighboring tissues. Ultrasonography and computed tomography may be helpful, but there are no pathognomonic data for their preoperative recognition. The differential diagnosis should include all other cystic tumors of the pancreas. Complete surgical removal is mandatory. We describe the diagnostic and surgical procedures in a 74 year-old man with a pre-operatively unsuspected dermoid cyst. We review the previously published cases and emphasize the appropriate therapeutical management.

Fine-needle aspiration of dermoid cyst of the pancreas: a case report. Diagn Cytopathol. 1993;9(1):66-9.

A 53-yr-old woman presented with a left upper quadrant abdominal mass attached to the body of the pancreas. Fine-needle aspiration (FNA) yielded cyst fluid containing numerous benign, mature squamous cells, keratin debris, and inflammatory cells. The diagnosis of dermoid cyst was subsequently rendered on the resected specimen. The cytologic and histologic features are presented. FNA cytology proves to be a valuable diagnostic adjunct in the preoperative evaluation of a patient with dermoid cyst of the pancreas.

Cystic teratomas of the pancreas. Arch Surg. 1990;125(9):1215-8.

Cystic teratomas of the pancreas constitute an extremely rare entity with only nine cases, to our knowledge, described in the world literature. Symptoms are usually due to the compressive effects of the tumor on the neighboring organs. They should be considered in the differential diagnosis of slow-growing benign pancreatic cysts. We describe a 25-year-old woman with a pancreatic teratoma who was operated on in 1976 with the diagnosis of calcified pancreatic cyst. The diagnostic and surgical procedures are described, as well as a 14-year follow-up. The previously published cases are reviewed and the differential diagnosis is discussed. Early diagnosis and the need for total tumor resection are emphasized.

Dermoid cyst of the pancreas. Case report and review of the literature. Gastroenterol Clin Biol. 1990;14(12):1023-5.

During an annual check-up in a 46 year-old man, a round mass was discovered in the left hypochondrium upon abdominal ultrasonography. Computed tomographic scan located the mass at the upper border of the body of the pancreas, suggesting an expansive process. Left pancreatectomy was performed, leading to the discovery of a dermoid cyst. This cyst was apparently part of the pancreatic parenchyma. Only 11 cases of dermoid cysts of the pancreas have been reported between 1918 and 1977. Elective enucleation of the cyst is thought to be adequate surgical treatment.

September 2007

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