Pancreatic Pathology Online

Pathology of Adenosquamous Carcinoma of the Pancreas

Dr Sampurna Roy MD              

 

Syn: Adenoacanthoma ; Mucoepidermoid carcinoma.

   

Adenosquamous carcinoma of the pancreas is a rare tumour which has a less favorable prognosis than common ductal cell carcinoma of  the pancreas, and a definite preoperative diagnosis of this tumour is quite difficult.

This tumour is considered a variant of ductal adenocarcinoma.

Adenosquamous carcinoma of the pancreas is a rare tumour, and because its presentation, clinical features, macroscopic appearance, and course are identical to adenocarcinoma of the pancreas, it  should be considered in the differential diagnosis for any mass of the head of the pancreas.

Microscopically, all tumours demonstrate dual differentiation toward adenocarcinoma and squamous cell carcinoma.

Occasionally, squamous elements may almost entirely obliterate the glandular component.

Extensive tissue sampling is necessary to demonstrate glandular component.

Rare unusual histological features include a pronounced acantholytic pattern within the squamous carcinoma component, and the presence of both osteoclastic and pleomorphic giant cells.

In metastatic tumours adenocarcinoma component is often prominent or may be the only component present.

Multidisciplinary treatments including aggressive surgery, intraoperative radiation therapy, and locoregional chemotherapy might improve the survival of patients with adenosquamous carcinoma of the pancreas to inhibit liver metastasis and local recurrence.

 

Further reading:

Adenosquamous carcinoma of the pancreas: a distinct clinicopathologic entity.

Resected pancreatic adenosquamous carcinoma: clinicopathologic review and evaluation of adjuvant chemotherapy and radiation in 38 patients.

Adenosquamous carcinoma of the pancreas: a clinicopathologic series of 25 cases.

Immunohistochemical characteristics of adenosquamous carcinoma of the pancreas.

Adenosquamous carcinoma of the pancreas: a clinico pathologic study.

Adenosquamous carcinoma of the pancreas.

Adenosquamous carcinoma of the pancreas: cytologic features in 14 cases.

Adenosquamous carcinoma of the pancreas with an acantholytic pattern together with osteoclast-like and pleomorphic giant cells.

Adenosquamous carcinoma of the pancreas with clear cell and rhabdoid components. A case report

Adenosquamous carcinoma of the pancreas.

Adenosquamous carcinoma of the pancreas: preoperative diagnosis and molecular alterations.

 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)


 

 

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