Pancreatic Pathology Online

Pathology of Inflammatory Pseudotumour

(Inflammatory Myofibroblastic Tumour) of the Pancreas

Dr Sampurna Roy MD            


Syn: Inflammatory pseudotumor ; Plasma cell granuloma

Pancreatic inflammatory pseudotumor is a rare lesion of the pancreas but it must be distinguished from pancreatic cancer.

The tumour is more common in lung.

Visit:  Myofibroblastic tumours of the soft tissue .

The lesion is probably not EBV-related.

Clinically the lesion generally presents with cholestasis and a mass lesion which may constrict bile duct  suspicious of malignancy.

Histologically, there is a hypocellular to moderately hypercellular, bland spindle-cell proliferation admixed with a prominent infiltrate of lymphocytes, histiocytes and plasma cells.

In rare cases, eosinophils are prominent.

The spindle cells are vimentin and smooth muscle actin positive.

The lesion is negative for S100 protein, Cytokeratin, CD35, LMP, EBER.

It can be extremely difficult to differentiate inflammatory myofibroblastic tumour from pancreatic malignancies.

Most cases require surgical exploration and complete resection to obtain an accurate diagnosis.


Further reading:

Inflammatory pseudotumor of the pancreas resembling pancreatic cancer: clinical, diagnostic and therapeutic considerations.

Inflammatory pseudotumor of the pancreas head in children.

Inflammatory pseudotumour of the pancreas in a child.

Inflammatory myofibroblastic tumor presenting as a pancreatic mass: a case report and review of the literature.

Retroperitoneal inflammatory pseudotumor presenting as a pancreatic mass.

Laparoscopic distal pancreatectomy for inflammatory pseudotumor of the pancreas. 

Oligoclonal T-cell populations in an inflammatory pseudotumor of the pancreas possibly related to autoimmune pancreatitis: an immunohistochemical and molecular analysis.

Inflammatory myofibroblastic tumor of the pancreatic head.

Inflammatory myofibroblastic tumour of the pancreas.

Inflammatory myofibroblastic tumor (IMT) of the pancreas.

Inflammatory pseudotumor from sclerosing cholangitis.

Inflammatory pseudotumor of the pancreas.

Inflammatory pseudotumour arising from periampullary carcinoid: a "cancer-like" tumour in a "fake" tumour.

Inflammatory pseudotumor presenting as a cystic tumor of the pancreas.




Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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