Osteomas of the skin revisited: a clinicopathologic review of 74
cases.
Am J
Dermatopathol. 2002 Dec;24(6):479-83.
Cutaneous
ossification is an unusual event that may be primary or secondary to
either inflammatory or neoplastic processes. It is classified as
primary when it occurs in the absence of a demonstrable preexisting
lesion. Secondary lesions have been most commonly reported occurring
with pilomatricoma, basal cell carcinoma, acne vulgaris, and
melanocytic nevi (nevus of Nanta). Histologically, the osteomas are
composed of well-formed bony spicules with prominent cement lines and
calcification. They may demonstrate osteoblasts, osteoclasts, and
osteocytes and occasionally may even demonstrate bone marrow elements.
We searched the files of a reference dermatopathology laboratory to
identify cases of either primary or secondary cutaneous ossification.
We present a series of 74 cases of primary and secondary cutaneous
ossification. Most cases were secondary in nature. Lesions were more
common on the head and neck and in whites. Lesions were also more
commonly identified in female patients. In addition, included in our
series are 19 cases of nevus of Nanta. To our knowledge, this
represents the largest series of such cases in the English literature.
Cutaneous ossification is seen both in primary and, more commonly, in
secondary conditions involving the skin. Benign neoplasms, especially
melanocytic nevi, represent the most common cause of secondary osteoma
formation. Women are more commonly affected than men, but the reason
for this is unclear. The exact reason why osteoma formation occurs is
unclear and requires further study.
Multiple miliary
osteomas of the face.J
Dtsch Dermatol Ges. 2003 Feb;1(2):131-3
A 60-year-old
man presented with multiple miliary osteomas of the face. This rare
type of osteoma cutis is characterized by milia-like extra-skeletal
bone formation in the cutis and/or subcutis of the face.
Histologically, bony trabeculae with peripheral osteoblasts can be
found next to lipocytes and haematopoietic cells. Primary osteoma
seems to be derived from residual aberrant embryonic mesenchymal
tissue. Surgical therapy is the most efficient treatment. We review
clinical features, aetiology and therapy.
Miliary osteoma of
the face: a report of 4 cases and review of the literature.Cutis.
2002 May;69(5):383-6
Osteoma cutis (OC)
is a rare disorder characterized by compact bone formation in the
dermis and subcutaneous tissue. It is classified in primary and
secondary forms according to the presence or absence of previous
cutaneous lesions. Miliary osteoma of the face (MOF) is a form of
primary OC that generally occurs in middle-aged and older adult women.
We report 3 cases of typical MOF and one additional case in a black
patient, which to our knowledge has not been described previously.
Primary osteoma
cutis. Clinical, morphological, and ultrastructural study.Am
J Dermatopathol. 1993 Feb;15(1):77-81
Primary osteoma
cutis arises in the deeper dermis for no apparent reason and presents
as mature, lamellar, and osteonic bone; secondary cutaneous osteomas
are correlated with inflammatory processes, scars, or dysembryoplasia
and are always composed of osteoid. Ultrastructural findings of
primary cutaneous osteomas have not been reported to date. Light and
electron microscopic findings of a case of primary osteoma cutis are
described: mineralized areas may be divided into macrocalcification
and microcalcification. Macrocalcification consists of lamellar bone.
Osteocytes populate the lamellae, whereas collagen fibril distribution
is bone-like. Hydroxyapatite deposition presents as globular or
needle-like electron-dense material progressively masking the
connective tissue matrix. Microcalcifications, which are found in
macroscopically normal dermis around the calcified plaque, consist of
osteoid tissue inhabited by osteoblast-like cells. Microcalcifications
may be interpreted as metastatic calcifications related to the primary
osteoma calcified plaque. Primary osteoma cutis may be considered as
true bone amartothic formation rather than dermal mineralization.
Osteoma cutis.
Multiple miliary osteoma of the face.Hautarzt.
1993 Apr;44 (4):245-7
Primary and
secondary forms of ossification can be distinguished on the basis of
the skin, with osteoma cutis occurring in primary forms. Three
entities can be differentiated: solitary and generalized osteoma cutis
and multiple miliary osteoma of the face. Clinically, multiple papules
2-3 mm in diameter are present, which histologically consist of bony
trabeculae enclosing mature fat cells and, occasionally, marrow cells.
We describe the clinical, radiological and histological features of a
case of multiple miliary osteoma of the face in an otherwise healthy
55-year-old woman.
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