Pancreatic Pathology Online

Pathology of Microglandular Adenocarcinoma of the Pancreas

Dr Sampurna Roy MD                  June 2016

 

The term microadenocarcinoma was first proposed for a subtype of pancreatic carcinoma in 1975. 

The tumour shows distinctive microglandular and solid cribriform pattern.

Immunohistochemical re-evaluation (Cubilla and Fitzgerald) revealed that microglandular adenocarcinoma does not constitute an entity of its own, but comprises a group of tumours with heterogeneous histologic features and immunostaining patterns.

Exocrine Pancreatic Tumours.

These tumours should be classified with ductal adenocarcinoma having neuroendocrine, acinar or mixed immunohistochemical phenotype.

The main importance of recognizing this rare variant of pancreatic adenocarcinoma lies in avoiding misdiagnosis with other primary and metastatic neuroendocrine neoplasms of this organ.

Immunohistochemical and ultrastructural examination will  be of value in such cases for differential diagnosis.

Microadenocarcinoma is best regarded as a pattern of growth associated with an aggressive clinical course rather than a distinctive entity.

 

Further reading:

Morphological patterns of primary nonendocrine human pancreas carcinoma.

Microadenocarcinoma of the pancreas.

Microadenocarcinoma in the head of the pancreas.

Microadenocarcinoma of the pancreas--morphologic pattern or pathologic entity? A reevaluation of the original series.

Survival in 1001 patients with carcinoma of the pancreas.

Morphological study of 391 cases of exocrine pancreatic tumours with special reference to the classification of exocrine pancreatic carcinoma.

 

 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)


 

 

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