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Pancreatic Pathology Online
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Exocrine Pancreatic Tumours.
Recent
immunohistochemical re-evaluation (Cubilla & Fitzgerald)
revealed
that microglandular adenocarcinoma does not constitute
an entity of
its own, but comprises a group of tumours with
heterogeneous histologic
features and immunostaining patterns.
These tumours should be
classified with ductal adenocarcinoma
having neuroendocrine, acinar or
mixed immunohistochemical
phenotype.
The main
importance of recognizing this rare variant of pancreatic
adenocarcinoma
lies in avoiding misdiagnosis with other primary and
metastatic
neuroendocrine neoplasms of this organ.
Immunohistochemical and ultrastructural examination will be of value
in such cases for
differential diagnosis.
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