Pancreatic Pathology Online

Pathology of Eosinophilic Pancreatitis

Dr Sampurna Roy MD             

 

Eosinophilic pancreatitis (EP) is a rare disease.

It typically occurs in the setting of either eosinophilic gastroenteritis or the hypereosinophilic syndrome.

Isolated eosinophilic infiltration of the pancreas is less common.     

Clinical presentation: EP usually presents as a pancreatic tumour with abdominal pain and/or obstructive jaundice.

The diagnosis is often not made until after pancreatic resection under suspicion of a pancreatic tumour.

Diagram of eosinophilic pancreatitis

Microscopic features:  Patients with eosinophilic pancreatitis may show two distinct histologic patterns:

1) a diffuse periductal, acinar, and septal eosinophilic infiltrate with eosinophilic phlebitis and arteritis; and 

2) localized intense eosinophilic infiltrates associated with pseudocyst formation.

Differential diagnosis: Prominent eosinophilic infiltrates are an unusual finding in the pancreas. 

Other causes of eosinophilic infiltrates include pancreatic allograft rejection, pancreatic pseudocyst, lymphoplasmacytic sclerosing pancreatitis (LPSP), inflammatory myofibroblastic tumor, and histiocytosis X.

                                                                                    

Visit:  Non-Neoplastic Pancreatic Cysts including Congenital and Pseudocysts ; Lymphoplasmacytic Sclerosing (Autoimmune) Pancreatitis ; Inflammatory Pseudotumour (Inflammatory Myofibroblastic Tumour) ;

 

 

Further reading

Eosinophilic cell pancreatitis in newborn infants of diabetic mothers.

Pancreatitis and eosinophilic gastroenteritis.

Eosinophilic infiltration of duodenum and pancreatic head: report of a case studied arteriographically.

Eosinophilic pancreatitis in the newborn infant of a diabetic mother

Eosinophilic pancreatitis: a rare manifestation of digestive allergy?.

Eosinophilic pancreatitis: report of a case.

A case of chronic pancreatitis with eosinophilic pleural effusion.

Eosinophilic gastroenteritis presenting with acute pancreatitis.

Panniculitis with eosinophilic infiltration due to gabexate mesilate (FOY): possibility of allergic reaction.

Eosinophilic pancreatitis and increased eosinophils in the pancreas

Endoscopic ultrasound-guided fine needle aspiration cytology of intraductal papillary mucinous tumor of the pancreas. A case report.

A case of eosinophilic pancreatitis.

Eosinophilic pancreatitis presenting as a pancreatic mass with obstructive jaundice.

Eosinophilic pancreatitis mimicking pancreatic neoplasia.

 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)


 

 

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