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Sinonasal inverted
papilloma with malignant transformation in the middle ear: a
multicentric origin? J Laryngol Otol.2006 Jul;120(7):597-9.
Inverted
papilloma is a rare, benign tumour representing only 0.5 to 4 per
cent of all sinonasal neoplasms; its involvement of the middle ear
is extremely rare. We present a case of multicentric inverted
papilloma in the sinonasal region and middle ear in a 54-year-old
man. The patient later developed neck metastasis secondary to
malignant transformation of the inverted papilloma in the middle
ear.
Middle ear
squamous papilloma: report of a case and literature review. Rev Bras
Otorrhinolaringol (Eng Ed).2005 May-Jun;71(3):396-8.
Squamous
papillomas are benign neoplasms. The occurrence of middle ear
squamous papilloma is rare. It is usually associated with
nasosinusal pathology. The authors report a case of middle ear
squamous papilloma and discuss its diagnostic aspects.
Primary inverted
papilloma of the middle ear and mastoid.Otol Neurotol. 2002
Jul;23(4):555-9.
OBJECTIVE:
Inverted papilloma (Schneiderian-type papilloma), involving the
middle ear and mastoid as a primary lesion or as an extension of a
sinonasal papilloma, is an extremely rare occurrence. STUDY DESIGN:
The study design was a case report format with a review of the
literature. Epidemiologic, diagnostic, therapeutic and follow-up
problems are discussed. SETTING: Academic, tertiary referral
hospital. PATIENT AND METHODS: The patient underwent Wullstein type
I tympanoplasty and complete mastoidectomy, revealing obliteration
of the pneumatic cells by polypoid tissue. The middle ear was
completely filled by polypoid tissue. Histopathologic examination
revealed an inverted papilloma of the middle ear and mastoid.
CONCLUSION: Literature reports indicate that inverted papillomas of
the middle ear and mastoid differ pathogenically and
epidemiologically from sinonasal inverted papillomas. Recurrence
rates and association with squamous cell carcinoma are higher in
Schneiderian-type papillomas of the middle ear than in inverted
papillomas of the nose and paranasal sinuses. Long-term follow-up
after removal of inverted papilloma of the middle ear and mastoid is
mandatory. Magnetic resonance imaging is the first follow-up
examination to perform.
Inverting
papilloma of the temporal bone. Laryngoscope.2002 Jan; 112 (1):140-2.
OBJECTIVES:
Inverting papilloma of the temporal bone is exceedingly rare. The
objective is to familiarize the clinician with the clinical
presentation and prognosis of this entity. STUDY DESIGN:
Retrospective case study and literature review. METHODS: Published
reports of inverting papillomas originating in the temporal bone
were reviewed in conjunction with two cases presenting at the
University of Texas Medical Branch (Galveston, TX). RESULTS:
Inverting papillomas of the temporal bone are frequently associated
with persistent middle ear effusion and ipsilateral sinonasal tumors
and display a higher incidence of malignancy. CONCLUSIONS:
Successful management of these tumors requires an aggressive
surgical resection. Adjuvant radiation therapy is recommended in
patients with malignant changes.
Clinical and
molecular pathology of aggressive Schneiderian papilloma involving
the temporal bone.Head Neck.1998 Jan;20(1):83-8.
BACKGROUND:
Inverting papilloma is a benign but locally aggressive sinonasal
tumor that rarely involves the middle ear or temporal bone. METHODS:
A report of a case and the molecular pathology of the tumor is
presented. RESULTS: A 35-year-old woman with a history of recurrent
inverting papilloma of the left paranasal sinuses was found to have
evidence of extension through the eustachian tube and extensive
involvement of the temporal bone. Surgical management resulted in
the patient being disease-free at 14 months. Molecular pathology
studies of the resected tumor suggest an association with human
papillomavirus. CONCLUSIONS: Direct extension of the sinonasal tumor
through the eustachian tube may represent the pathologic mechanism
involved in the development of inverting papilloma involving the
middle ear and temporal bone.
Schneiderian-type
mucosal papillomas of the middle ear and mastoid. Ann Otol Rhinol
Laryngol.1996 Mar;105(3):226-33.
Five cases
of schneiderian-type mucosal papillomas arising in the middle ear
space are reported. The patients were all women, ranging in age from
19 to 57 years (median, 31 years). Clinical complaints--unilateral
conductive hearing loss, pain, or otorrhea--ranged from those
lasting several months to recurrent problems spanning 20 years. All
of the patients had a history of chronic otitis media predating the
development of the papillomas; none of the patients had a history of
sinonasal or nasopharyngeal schneiderian-type papillomas.
Clinically, three patients had intact tympanic membranes, while the
other two patients had perforated tympanic membranes through which a
bulging polypoid mass was identified. Radiographic studies showed
opacification of the middle ear space without evidence of osseous
destruction. The intraoperative findings were of polypoid lesions
filling the middle ear space, including involvement of the
eustachian tube orifice. Histologically, the tumors were identical
to sinonasal schneiderian papillomas. Immunohistochemical evaluation
for human papillomavirus was negative. Surgical excision is the
treatment of choice. In four of the patients, recurrent tumor was
identified, necessitating additional surgery. In only one patient
did the initial surgery result in complete ablation of the tumor.
All patients are alive and free of recurrent disease over periods
ranging from 6 months to 120 months (median, 84 months).
Dissemination of
squamous papilloma by surgical manipulation: a case report.
Laryngoscope.1984 Dec;94(12 Pt 1):1568-70.
The
occurrence of multiple squamous cell papilloma in the upper and
lower aerodigestive tract is well documented. While apparent
inoculation to other areas in the lower respiratory tract at the
time of bronchoscopy or tracheotomy is a frequently described
occurrence, there have, however, been no reports of transmission of
papilloma outside the respiratory tract as a result of surgical
manipulation. The purpose of this paper is to report a case of
squamous papilloma of the external auditory canal and tympanic
membrane which resulted from apparent inoculation at the time of
surgery for nasal cavity and nasopharyngeal papillomas together with
myringotomies. This supports the hypothesis that an infectious
agent, e.g., a virus could be the causative agent and that
inoculation to other sites as a result of manipulation is possible.
In light of our experience with this case we recommend specific
guidelines for the handling of these patients and the protection of
surgeons, anesthesia and operating room personnel. Hopefully this
report will heighten awareness of papillomas as a potentially
transmittable entity to sites outside the respiratory tract, and
encourage others to approach these clinical situations with caution.
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