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Malakoplakia
outside the urinary tract.: Arch Pathol Lab Med.2007
Feb;131(2):297-300.
CONTEXT:
Malakoplakia is a rare granulomatous disease that occurs commonly in
the urinary tract. Histologically, it is defined by sheets of
histiocytes (Hansemann cells) with accumulation of granular
basophilic periodic acid-Schiff-positive, diastase-resistant
inclusions and calcified Michaelis-Gutmann bodies, which are
pathognomonic but not necessary for diagnosis. In addition to the
urinary tract, malakoplakia has been reported in other organs,
including the gastrointestinal tract, central nervous system, female
genital tract, and the tongue. OBJECTIVES: To review the literature
of reported sites of malakoplakia outside the urinary tract and
their variable clinical presentations, and to discuss the main
diagnostic features and differential diagnoses of malakoplakia. The
pathogenesis and possible etiologic factors are also presented. DATA
SOURCES: Data for this work were collected from the published
literature, textbooks, and the Internet. CONCLUSIONS: It is
important to be aware of the existence of this entity in abnormal
locations. In many situations, malignancy can be mimicked,
especially when the lesion is ulcerated and is accompanied by lymph
node involvement. Misinterpreting large, rapidly growing nodules of
malakoplakia as tumor might lead to overstaging. Pathologists should
be also aware of the possibility of malakoplakia coexisting with
other lesions, such as tuberculosis and carcinoma, in the same
specimen.
Malakoplakia of
the middle ear. Histopathology.1991 Sep;19(3):276-8.
Malakoplakia of
middle ear: a case report. Histopathology.1983 Jan;7(1):129-34
Case presentation
of malacoplakia of the middle ear. Acta Otorrinolaringol Esp.1995
Jul-Aug;46(4):315-6.
Malakoplakia
is a chronic inflammatory process usually located in the urinary
bladder but it may occasionally affect other organs. It is a rarely
found in ENT cases. Such a case was diagnosed and treated in our
department. Possible pathogenesis is also discussed.
Malakoplakia of
the temporal bone in a nine-month-old infant. J Laryngol Otol.1991
Jul;105(7):568-70.
A case
of malakoplakia, of the temporal bone in a nine-month-old male child
is reported. The lesion presented as an aural polyp, associated with
a lower motor neuron facial palsy. On exploration, the granuloma was
noted to involve the temporal bone, eroding the bony labyrinth. It
was successfully treated with surgical debridement, and antibiotics.
A review of the relevant literature is presented.
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