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Primary cutaneous aggressive epidermotropic CD8 positive
cytotoxic T-cell lymphoma of the ear.J
Laryngol Otol. 2007 May;121(5):503-5.
We report a
case of an epidermotropic CD8+ cutaneous T-cell lymphoma which
initially presented as an ulcerated lesion of the pinna. Although
T-cell lymphomas may present as cutaneous lesions, the ear is rarely
involved. This uncommon presentation and the need for multiple
biopsies means that the diagnosis of these lesions may be delayed or
missed. A high index of suspicion is required when evaluating
cutaneous lesions in the head and neck area.
Primary B
cell lymphoma of the external auditory canal.Ear
Nose Throat J. 2006 Sep;85(9):597-9.
Temporal
bone lymphomas are rare and typically metastatic neoplasms. We
describe a case of primary B cell lymphoma that originated in the
external auditory canal of an elderly woman. The diagnosis was based
on histopathologic examination supplemented by immunophenotypic
analysis. The patient was treated with external-beam radiation and
remained disease-free throughout 9 years of follow-up. We also point
out that the presence of non-Hodgkin's lymphoma in an unusual site
may be an indication that the patient has an acquired
immunodeficiency syndrome.
De novo
CD5-positive diffuse large B-cell lymphoma of the temporal bone
presenting with an external auditory canal tumor.
Intern Med. 2006;45(11):733-7.
We report a
74-year-old woman with primary CD5-positive diffuse large B-cell
lymphoma (DLBCL) of the temporal bone. The patient was admitted
because of a mass in the left external auditory canal. She was
treated with eight courses of CEOP therapy (rituximab was added from
the sixth course) followed by radiotherapy of 40 Gy, and complete
remission was achieved. The occurrence of malignant lymphoma in the
temporal bone, which is an extremely unusual site, may have depended
on the peculiarity of CD5-positive DLBCL.
Primary
middle-ear lymphoma in a child.J
Laryngol Otol. 2003 Mar;117 (3):205-7.
The case of
a five year old boy who presented with a lower motor neurone facial
nerve palsy secondary to primary non-Hodgkin's lymphoma (NHL) of the
middle ear is discussed. Any child who presents with a facial nerve
palsy and conductive hearing loss requires thorough evaluation to
exclude the possibility of temporal bone malignancy.
Systemic
B-cell lymphoma presenting as an isolated lesion on the ear.Clin
Exp Dermatol. 2001 Mar;26(2):166-9.
We report a
case of systemic B-cell lymphoma that presented as an isolated
cutaneous lesion on the ear, mimicking a primary cutaneous B-cell
lymphoma. Although there was no clinical evidence of systemic
disease, bone marrow involvement was found on further investigation
and subsequent immunoglobulin gene analysis revealed an identical
clone in the skin lesion and bone marrow aspirate. Evidence of a
t(14 : 18) translocation was not identified. This case is unusual
for several reasons. First, involvement of the pinna as a presenting
feature of systemic lymphoma has not been reported previously.
Second, the cutaneous lesion had been present for 3 years prior to
diagnosis and there has been no clinical progression of systemic
lymphoma during 2 years of follow-up. Third, the lymphoma does not
correspond exactly to any of the entities in the REAL classification
of systemic B-cell lymphoma. This case underlines the indolent
nature of some systemic B-cell lymphomas and the need to investigate
thoroughly patients with disease apparently confined to the skin.
Lymphoma in
the ear.ORL
J Otorhinolaryngol Relat Spec. 2000
Sep-Oct;62(5):274-7.
BACKGROUND:
Malignant tumors of the ear are rare. The most common malignant
tumors are squamous cell carcinomas and adenocarcinomas. Lymphoma in
the ear is rare. METHODS: We report 2 cases of a primary
presentation of a lymphoma of the ear. The literature since 1947 is
reviewed. RESULTS: An 83-year-old woman with an anaplastic large
cell lymphoma of the skin of the external auditory meatus and a
75-year-old man with a B-cell non-Hodgkin's lymphoma of the mastoid
process are presented. The literature review shows that only 16
cases of lymphomas of the ear have been reported so far.
CONCLUSIONS: In a case of therapy-resistant otitis and/or peripheral
facial paralysis malignancy should be excluded by computer
tomography of the mastoid. For histopathological diagnosis unfixed
specimens are preferable. Uniform treatment of lymphomas of the ear
has not been established.
Lymphoma of
the tympanic membrane in acquired immunodeficiency syndrome.Auris
Nasus Larynx. 1998 Jan;25(1):89-94.
Lymphoproliferative disease is more common in the immunocompromised
host and can occur at unusual sites. Lymphomas of the temporal bone
are rare. We present the first case of a large B-cell Lymphoma of
the tympanic membrane in a patient with acquired immunodeficiency
syndrome. The tympanic membrane is a site rich with
antigen-presenting dendritic cells that may play an etiologic role
in neoplastic transformation at this site. The staging, treatment
and prognosis of an immunocompromised host afflicted with lymphoma
is discussed. Future directions in improving survival include better
therapy for the primary viral infection and less toxic therapy for
the lymphoma.
Petrous bone
tumors: primary non-Hodgkin lymphoma of the inner ear canal and
cerebellopontile angle.Laryngorhinootologie.
1997 Oct;76(10):625-8.
BACKGROUND:
We report about a primary Non-Hodgkin Lymphoma (NHL) of the internal
auditory canal. The only previously known manifestations of a NHL in
the temporal bone have been infiltrations or hemorrhagic
complications due to a late manifestation or advanced systemic
disease. Involvement of both temporal bones is typical. CLINICAL
CASE: The 60-year-old female patient complained of an acute
one-sided deafness, accompanied by a high-pitched tinnitus, rotating
vertigo, and paralysis of the left half of the face. RESULTS: We
found a deafness in the left ear, spontaneous nystaxis, which was
interpreted as a deficiency in excitement of the vestibular organ,
and a complete peripheral facial paralysis. Diagnostic imaging
studies revealed a large, intrameatal solid mass in the temporal
bone, measuring 1.2 x 0.8 cm. Histologic examination after
translabyrinthine tumor removal demonstrated a centroblastic
Non-Hodgkin Lymphoma. The following extensive interdisciplinary
staging examination showed no other tumor manifestations; the CSF
analysis was negative. CONCLUSIONS: The uniqueness of this case lies
in the detection of a primary nongeneralized centroblastic lymphoma
of the internal auditory canal. In contrast to infiltrations of
systemic NHL in the same location, in which the advanced disease is
responsible for the bad prognosis, this isolated lymphoma of the
internal auditory canal seems analogous to extranodal MALT Lymphomas
with a better prognosis. The primary extranodal NHL of the temporal
bone, not reported in previous studies, is discussed with regard to
clinical symptoms, differential diagnoses, and therapeutic
strategies.
Primary
lymphoma of the internal auditory canal. Case report and review of
the literature.Ann
Otol Rhinol Laryngol. 1998
Jan;107(1):17-21.
We report a
rare case of a primary intracranial B cell lymphoma originating in
the internal auditory canal. The clinical manifestations were
indistinguishable from those of other, more common tumors of the
same region. We achieved total gross tumor removal with preservation
of the facial nerve. A detailed histologic examination and a
systemic workup confirmed the primary nature of this tumor. To our
knowledge, this is the second case reported in the literature of a
primary malignant lymphoma originating in the internal auditory
canal. This is the first instance that includes immunohistochemical
and cytometric studies of fresh tissue. We discuss the management of
primary lymphomas of the central nervous system, with special
emphasis on their association with acquired immunodeficiency
syndrome and other immune system diseases. Awareness of primary
central nervous system lymphomas is important, since a greater
occurrence of these rare tumors in the cerebellopontine angle is
probable in the future.
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