| Presence
of Epstein-Barr virus in lymphoepithelioma-like carcinoma of the
middle ear. J Clin Pathol.1998 Aug;51(8):602-5.
AIM: To
examine the association of Epstein-Barr virus (EBV) with carcinoma
of the ear. METHODS: Five non-keratinising squamous cell carcinomas
and two undifferentiated carcinomas of the ear were examined. In
situ hybridisation was used to localised EBV-encoded RNAs (EBER).
Immunohistochemical methods to detect LMP-1 and EBNA2 were performed
in the EBER positive cases. RESULTS: Two cases were EBER positive,
including one non-keratinising and one undifferentiated carcinoma.
Both showed identical morphology to those arising from the
nasopharynx, with abundant lymphoid stroma. They were both negative
for LMP-1 and EBNA2. CONCLUSIONS: EBV associated carcinoma with the
morphology of lymphoepithelioma can also arise from the middle ear.
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