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                Gout of Ear


 

                
Calcification of ear auricles is an uncommon clinical sign which is associated to gout, local traumatisms, addisonian crisis, and several endocrine diseases.

Primary Gout :  90% of cases. Majority of cases (idiopathic) are due  to overproduction of uric acid. About 5% cases there is known enzyme defect.  The disease is seen in conditions such as partial HGPRT deficiency.

Secondary Gout: 10% of cases. Associated with increased nuclei acid turnover such as leukemia. There is overproduction of uric acid with increased urinary excretion. Secondary Gout may be associated with chronic renal disease.

- Acute arthritis : Dense neutrophilic infiltrate in synovium and fluid
Monosodium urate crystals within neutrophil cytoplasm.

- Chronic tophaceous arthritis : Hyperplastic synovium with inflammatory cells and fibrosis, heavily encrusted with urate crystals.

 Visit: Gouty Tophus ; Case history and images .

- Tophi :  Pathognomonic hallmark of gout. Large aggregations of urate crystals surrounded by epithelioid histiocytes and mononuclear cells and foreign body giant cells.

Differential diagnosis:  Pseudogout  ;  Elastotic nodules of the ears may be diagnosed clinically as basal cell carcinoma, amyloid or even gout. Although elastotic nodules are usually found on the antihelix of the ear, they may arise on the helix and simulate chondrodermatitis nodularis helicis.

                  

Tophaceous gout and pseudogout of the middle ear and the infratemporal fossa: case report and review of the literature. J Otolaryngol. 2003 Aug;32(4):269-72.

Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 29-1996. A 59-year-old man with gout and a painful preauricular mass.N Engl J Med.1996 Sep 19;335(12):876-81.

Gout tophus of the middle ear. HNO.1990 Dec;38(12):465-7.

An unusual case of a patient with a gouty tophus in the middle ear is presented. The patient had no clinical or laboratory signs of hyperuricaemia. The findings in the middle ear are discussed with reference to current knowledge of the pathogenesis of gout.

Infratemporal gout tophus--a rare differential diagnosis in primary parotid gland disease. Laryngorhinootologie.1989 Nov;68(11):638-41.

Soft-tissue tophi can be observed in up to 50% of patients with primary gout. They are firm deposits of monosodium urate in crystal form, which develop from pinhead-size to egg-size in the subcutaneous tissue. In the field of ear, nose, and throat diseases tophi have been described in such rare locations as the wing of the nose, the tongue, the epiglottis, and the arytenoid and thyroid cartilage. Tophus formation at the temporomandibular joint with extension into the fossa infratemporalis has been mentioned only three times in the world literature. -In the present paper, the authors report on the extraordinary location of an urate tophus in the fossa infratemporalis - in this case, there was even destruction of the middle base of the skull - which had been misinterpreted for years, having been diagnosed as a primary disease of the parotid gland.

A gouty tophus in the temporomandibular joint and on the eustachian tube. Laryngol Rhinol Otol (Stuttg).1983 Dec;62(12):574-7.

A 76-year old female patient was suffering from a right-sided conduction-type hearing loss due to a very painful tumour in the anterior parotid region. X-ray films showed a partial destruction of the right temporomandibular joint. Since the patient had undergone a left-sided mastectomy for breast carcinoma two years previously, an operation was performed under the suspicion of a metastatic lesion. A plum-sized gouty tophus was found adjacent to the temporomandibular joint. The head of the mandible was partly destroyed, the upper pole of the parotid gland displaced and atrophic. The dorsal and medial aspect of the tophus impinged on the cartilaginous portion of the Eustachian tube. In the postoperative course, the conduction-type deafness disappeared, the pain was relieved, and the mobility of the joint almost completely restored. To our knowledge this represents the second case of a gouty tophus in the temporomandibular joint, the first one where the size of the lesion resulted in impingement of the Eustachian tube and conduction-type deafness. It is noteworthy that the patient showed no other signs or symptoms of primary gouty arthritis.


November 2007

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Accessory Tragus

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