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Primary cutaneous
amyloidosis of the auricular concha: case report and review of
published work. J Dermatol. 2006 Feb;33(2):128-31.
A
70-year-old Japanese female developed tiny papules on her bilateral
ears 2 years previously. A histological study of a biopsy specimen
revealed that amorphous materials were present in the widened dermal
papillae. Because these materials were positive for both Congo red
and Dylon, we diagnosed the lesion as primary cutaneous amyloidosis
of the auricular concha. Immunohistochemically, the amyloid
substance stained positively with 34betaE12 (cytokeratin 1/5/10/14),
suggesting that it had an epidermal origin. Seven reported cases of
this unique disorder were also reviewed.
Lichen
amyloidosis of the auricular concha: report of two cases and review
of the literature. Dermatol Online J. 2006 Sep 8;12(5):1.
Two cases
of lichen amyloidosis of the auricular concha are presented here,
supplementing the already approximately twenty cases of lichen
amyloidosis of the auricular concha reported to date. The first
patient is a 60-year-old woman who presented with a 4-year history
of an itchy rash that started in the bowl of her left ear, and soon
after appeared on the right side as well. The second patient is a
44-year-old woman who presented with a long-standing pruritic rash
on her upper back. This had become noticeably darker over the past
several years. In one of the two cases lichen amyloidosis of the
auricular concha reported here, concomitant macular amyloidosis of
the back was present. Combined cases of lichen and macular
amyloidosis are termed biphasic amyloidosis, and provide support to
the theory that these two variants of amyloidosis exist on the same
disease spectrum.
Otologic
manifestations of amyloidosis. Otol Neurotol.2002;23(2): 158-9.
OBJECTIVE:
To describe otologic manifestations of amyloidosis. STUDY DESIGN:
Retrospective case review. SETTING: Tertiary referral center.
PATIENTS: Case report of a patient with bilateral external auditory
meatal stenosis secondary to amyloidosis. RESULTS: The patient is a
60-year-old man who presented with several months' history of
bilateral ear blockage and drainage. Physical examination revealed
markedly thickened skin in each ear in the area of concha and meatus
that was associated with fissuring. The meatus were markedly
stenosed. The medial aspect of the external auditory canal and the
tympanic membrane were normal. He had partial improvement on medical
therapy with topical steroid-containing eardrops and ointment. Past
medical history was positive for multiple myeloma. Meatal biopsy was
performed. Grossly, the tissue was hypovascular and markedly
thickened. Histopathologic examination was consistent with
amyloidosis. The patient was continued on topical steroid ointments,
frequent ear cleaning, and close follow-up. He was subsequently
diagnosed with systemic amyloidosis. A review of the literature was
done. Head and neck involvement with amyloidosis is reviewed, with
emphasis on otologic manifestations. CONCLUSION: Otologic
involvement with amyloidosis is extremely rare. The pathophysiology
may be related to the local factors in the external auditory canal.
Papules in the
auricular concha: lichen amyloidosus in a case of biphasic
amyloidosis. Dermatologica.1990;181(2):149-51.
We present
a patient with lichen amyloidosus on the ears and macular
amyloidosis on the back. These diagnoses were supported by
histological, histochemical and immunohistochemical studies. This is
to the best of our knowledge the first reported case of a biphasic
form of amyloidosis whose lichenoid counterpart consists of papules
on the ears. This suggests that primary cutaneous localized
amyloidosis may have peculiar clinical manifestations depending on
the location of the lesion.
Primary cutaneous
amyloidosis of the auricular concha. J Am Acad Dermatol.1988
Jan;18(1 Pt 1):19-25.
Several
patterns of primary cutaneous amyloidosis are recognized; in this
report of four cases, we define a new pattern in which the lesions
are composed of small papules grouped on the concha of the ear. The
lesions typically are not pruritic but slightly friable. They may be
present on both ears. The patients do not have lesions of
amyloidosis on other parts of the body and no known insult precedes
the appearance of lesions. This entity appears to have been
described previously as collagenous papules of the ear.
Histochemical and electron microscopic methods allow us to confirm
the amyloid nature of the substance. We believe this condition to be
a variant of primary cutaneous amyloidosis, particularly because
monoclonal antikeratin antibody EKH4, which has been positive in
lichenoid, macular, and skin epithelial tumor-associated amyloidoses,
was positive in our cases.
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