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Merkel cell tumour of
the external ear. Report of a case. Auris Nasus Larynx.2007
Jun;34(2):229-32.
Merkel cells
carcinoma (MCC) is an uncommon skin lesion, considered a malignancy
of the neuroendocrine system, which is found mainly in elderly
people. Its incidence is highly correlated with sun exposure or
immunodeficiency syndromes. MCC is often an aggressive tumour with
high tendency for local recurrence, lymph node involvement and
distant metastasis. To our best knowledge 20 cases originated from
the auricle have been described, 2 of them arising from external ear
canal. The authors report a case of the ear canal characterized by
two others synchronous tumours and the occurrence of a malignant
high grade lymphoma, in which contribute of the pathologist was
essential for a critical review. MCC diagnosis is not always easy
for its pathological and clinical features and it should always be
considered in presence of lymphoma. A multidisciplinary approach is
basic.
Merkel cell
carcinoma of the auricle. Am J Otolaryngol. 2005 Sep-Oct;
26(5):324-6.
Merkel cell
carcinoma is a rare malignant tumor of the skin. The face and
extremities are the most common locations. We present a case of
Merkel cell carcinoma of the auricle in a 93-year-old man
subsequently treated with surgery and radiotherapy. The clinical
features, prognosis, and treatment of the Merkel cell carcinoma are
discussed.
Merkel cell
carcinoma of the auricle. Acta Otolaryngol 2005;125(2):125 -9.
Merkel cell
carcinoma (MCC) is an uncommon cutaneous neoplasm which arises in
adults with a peak incidence in the sixth and seventh decades. MCC
most often arises in the head and neck area and extremities. Among
head and neck primary sites, auricular MCC has proven to be rare and
only 20 cases have been reported in the literature. Auricular MCC
follows the same aggressive course as has been documented for MCC
arising elsewhere: the tumor has a propensity for recurring locally
and metastasizing to regional lymph nodes and distant sites.
Location of MCC in the auricular regions does not appear to confer
any survival advantage compared with MCC arising elsewhere. The
mainstay of treatment is surgery, with attempts at complete surgical
excision being of paramount importance. What role regional node
dissection, radiation therapy and chemotherapy may play in the
standard treatment of auricular MCC remains to be clearly
established.
Merkel cell
carcinoma of the auricle. Eur Arch Otorhinolaryngol.2000
Dec;257(10):558-60.
Merkel cell
carcinoma is a rare, although increasingly recognized, malignant
tumor of the skin. The most common site of occurrence is the head
and neck (50%). Only five cases of this tumor on the auricle have
been reported previously. We present a further such case. The
incidence, clinical features, diagnosis, prognosis, and treatment of
the Merkel cell carcinoma are discussed.
Merkel cell
carcinoma of the auricle. Otolaryngol Pol.1998;52(4):471-4.
A case of a
80-year-old woman suffering from Merkel cell carcinoma of the
auricle with regional cervical lymph nodes metastases has been
described. Surgical treatment (tumour and regional lymph nodes
dissection) was applied at first. Metastasis to one lymph node was
established in postoperative histological examination. Chemotherapy
(farmorubicin, cyclophosphamide, vincristine) in 3 cycles was
applied within 2 months. In spite of the above, 4 months after
tumour excision, metastatic lymph node manifested in the neck.
Combined treatment, radical neck dissection and radiotherapy was
applied then.
Merkel cell
carcinoma of the external auditory canal invading the intracranial
compartment. Am J Otolaryngol.1998 Sep-Oct;19(5):330-4.
PURPOSE: To
report an unusual case of an intracranial extension of Merkel cell
carcinoma originating in the external ear canal and causing
neurological deficits. CASE REPORT: An 86-year-old woman, with a
16-month history of an external auditory canal mass, presented with
hemiparesis, facial paralysis, and obtundation. Radiographic images
showed an intracranial mass extending into the petrous bone. METHOD:
The patient had a craniotomy for intracranial tumor resection with
concurrent mastoidectomy for facial nerve decompression and
obtundation and hemiparesis were resolved. Residual tumor was
subsequently treated with adjuvant radiation therapy, and facial
nerve function consequently improved. CONCLUSION: Merkel cell tumors
rarely invade the intracranial compartments. Residual tumor and
neurological deficits may respond to adjuvant radiation therapy.
Merkel cell carcinoma of the pinna. J Laryngol Otol.1997
Dec;111(12): 1195-8.
Merkel cell
carcinoma is an increasingly recognized tumour of the skin. The
commonest presentation is the head and neck region. Only three cases
of this rare tumour have been reported on the pinna. A further such
case is presented here.
Cutaneous
neuroendocrine carcinoma of the external ear canal. Ann Otolaryngol
Chir Cervicofac.1994;111(2):111-4
Authors
report a case of a neuroendocrine carcinoma (Merkel cell tumor)
located in the external meatus. These tumors have a fearsome
prognostic. Immunohistochemical study has become indispensable to
make the diagnosis. A literature review is presented, and
therapeutic choices discussed. Wide and precocious surgical
resection is advised.
Primary
neuroendocrine carcinoma of the pavilion of the ear. Acta
Otorrinolaringol Esp.1991 Nov-Dec;42(6):429-32.
We present a
case of primary neuroendocrine carcinoma (Merkel cell carcinoma) of
the external ear and its treatment. This paper also deals with
histogenesis, pathology, clinical findings, diagnosis and treatment
of this tumor.
Merkel cell
carcinoma of the ear. Head Neck.1991 Jan-Feb;13(1):68-71.
All the
consultants agree that, given this patient's history, a common skin
tumor like squamous cell or basal cell carcinoma is unlikely.
Melanoma or Merkel cell carcinoma belong in the differential.
Interestingly, the consultants all suggest a biopsy of the lesion
prior to other testing, and because this tumor is so accessible, a
biopsy should not interfere with further testing or treatment. Drs.
Weymuller and Marks would then proceed with a CT scan; Dr. Ridge
favors an MRI scan. While a chest-ray is in order to rule out
metastases, Dr. Weymuller also suggests immunocytochemistry. All the
experts agree that the primary tumor should be excised. Dr.
Weymuller would perform a total parotidectomy with facial nerve
preservation, while Drs. Marks and Ridge suggest a superficial
parotidectomy with facial nerve preservation. Drs. Weymuller and
Ridge would also perform a modified radical neck dissection. In the
absence of cervical disease, Dr. Marks would treat the neck
primarily with radiotherapy. Only Dr. Weymuller favors immediate
reconstruction and would use a lower trapezius island flap or a
large rotational flap. Drs. Marks and Ridge prefer primary closure
or skin graft. Drs. Weymuller and Ridge would treat this patient
with combined therapy, giving radiotherapy to the primary area and
the neck postoperatively at a dose of 55-60 Gy. However, Dr. Marks
would treat the primary site postoperatively and the neck primarily
with radiotherapy. He would treat the primary site with 59.40 Gy and
the neck with 50.40 Gy.
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