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Epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia)

Kimura's disease

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Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare condition that demonstrates dermal or subcutaneous proliferation of endothelial cells associated with an inflammatory cell infiltrate and may occur in and around the ear (auricle and external canal).

The lesion is characterized by single or multiple smooth-top papules or plaques of varying colour.

The patient complains of pruritis and bleeding after scratching.

Microscopic features:  ALHE consists of anomalous vascular proliferations and varying degrees of nodular and diffuse lymphocytic infiltrates with eosinophils.  Visit: Ear Pathology Online.

Differential diagnosis: Hemangioma and angiosarcoma.

                 

Angiolymphoid hyperplasia with eosinophilia of the auricle: progression of histopathological changes. J Laryngol Otol. 2006 May;120(5):411-3.

Angiolymphoid hyperplasia with eosinophilia is a rare condition that demonstrates dermal or subcutaneous proliferation of endothelial cells associated with an inflammatory cell infiltrate. A case is reported, with emphasis on the histopathological features on repeated biopsies. The report serves to stress the importance of considering this condition in the differential diagnosis of lesions in and around the ear.

Angiolymphoid hyperplasia with eosinophilia associated to a squamous cell carcinoma of the ear. Dermatol Surg. 2004 Oct;30(10):1367-9.

BACKGROUND: Angiolymphoid hyperplasia with eosinophilia is a benign vascular proliferation that usually affects the head and neck region. METHOD: An 89-year-old man who had a squamous cell carcinoma on the posterior aspect of one ear developed lesions of angiolymphoid hyperplasia with eosinophilia on the anterior aspect of the same ear. RESULTS: After surgical treatment of the malignant neoplasm, the lesions of angiolymphoid hyperplasia with eosinophilia disappeared spontaneously. CONCLUSIONS: Damage to the vasculature of the ear by the malignant neoplasm or the release of angiogenic factors by the same neoplasm is a plausible explanation for the development and eventual resolution of the vascular proliferation.

Pathological lesions of the external auditory meatus: a review.: J R Soc Med. 1990 Jan;83(1):34-7.

A closer study of the pathology of the external auditory meatus shows that there are various non-neoplastic and neoplastic diseases of local origin which are of great clinico-pathological importance. These include Kimura's disease and angiolymphoid hyperplasia with eosinophilia; progressive necrotizing (or malignant) external otitis. Osteoma and ceruminoma are typical neoplasms of the external auditory meatus which is also the site of polypoid granulomatous or neoplastic structures arising from the middle ear cleft. These so-called 'aural polyps' often dismissed as of little or no diagnostic importance, may contain significant clues to a serious underlying infection or to a malignant neoplasm. Profuse bleeding may ensue on removal of such polyps. The histopathological features and their significance are described and discussed.

Angiolymphoid hyperplasia with eosinophilia of the external ear (Kimura's disease).ORL J Otorhinolaryngol Relat Spec. 1985;47(3):139-44.

A rare case of angiolymphoid hyperplasia with eosinophilia, or Kimura's disease, of the external ear, occurring in a 21-year-old woman, is reported. The lesion has recurred twice after surgical excision and corticosteroid therapy was then elected. The clinical and histological features of this disease are described.

Angiolymphoid hyperplasia with eosinophilia of the external ear canal.Arch Otolaryngol. 1981 May;107(5):316-9.

Angioblastic lymphoid hyperplasia with eosinophilia, or Kimura's disease, is a clinically and histopathologically recognized entity that is characterized by cutaneous nodules, proliferating blood vessels with atypical histiocyte-like endothelial cells, and numerous eosinophils. It has been treated with steroids and by surgical excision, irradiation, cryotherapy, and electrodesiccation. Persistent residual disease and local recurrence are frequent. We review the literature and report two cases that involve the ear. We present the histopathologic and clinical results of laser removal of a conchal and external canal lesion.


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Case Index

Infectious Disease Online; INDEX: A-D ; INDEX: E-L ; INDEX: M-P INDEX: Q-Z ; FUNGAL DISEASE ; VIRAL DISEASE.

Neoplasms of the External Ear

Squamous Cell Carcinoma of the External Ear ;

Verrucous Carcinoma of the External Ear

Basal cell carcinoma of the External Ear ;

Ceruminous Adenoma of the External Ear ;

Pleomorphic Adenoma of the External Ear ;

Syringocystadenoma Papilliferum of the External Ear ;

Cylindroma of the External Ear ;

Ceruminous Adenocarcinoma of the External Ear ;

Adenoid Cystic Carcinoma of the External Ear ;

Melanocytic Tumours of the External Ear ;