| Conjunctival
mucoepidermoid carcinoma in a patient with ocular cicatricial
pemphigoid and a review of the literature.Surv
Ophthalmol. 2006 Sep-Oct;51(5):513-9.
Invasive mucoepidermoid carcinoma
of the conjunctiva of the left lower eyelid was diagnosed in an
orbital exenteration specimen of a 57-year-old woman, after a biopsy
of the same lesion was originally diagnosed as invasive squamous cell
carcinoma. The woman was undergoing mitomycin C injections for ocular
cicatricial pemphigoid, diagnosed in the same eye 2 years prior to
identification of the neoplasm. The tumor invaded the cornea, sclera,
lacrimal gland, regional small nerves, and lymphatics, but did not
show intraocular involvement. The original biopsy specimen was
reassessed with stains for mucin and found to be mucoepidermoid
carcinoma of the conjunctiva. We reviewed 21 cases of mucoepidermoid
carcinoma of the conjunctiva described to date in the English
literature. We believe this number underestimates the true incidence
of this condition, as it is frequently misdiagnosed both clinically
and histopathologically. Evaluating suspected aggressive squamous cell
carcinoma with special stains for mucin generally helps to identify
mucoepidermoid carcinoma of the conjunctiva. More extensive surgical
excision than that used for squamous cell carcinoma should be
implemented in the management of mucoepidermoid carcinoma of the
conjunctiva to prevent recurrence.
Mucoepidermoid carcinoma of
the conjunctiva: a series of three cases.Ophthalmology.
2000 Apr;107(4):801-5.
OBJECTIVE: To detail the
clinical presentation and outcomes of currently available treatments
for mucoepidermoid carcinoma of the conjunctiva (MCC). DESIGN:
Retrospective noncomparative case series. PARTICIPANTS: Three patients
ranging from 40 to 63 years of age with MCC participated.
INTERVENTION: Excisional biopsies and various therapies were
performed. MAIN OUTCOME MEASURES: Clinical and surgical outcomes were
measured. RESULTS: Patient 1 is a 55-year-old man with right temporal
MCC. He underwent two local excisions with adjuvant cryotherapy and
has had no recurrence at 31 months follow-up. Patient 2 is a
63-year-old man with right temporal MCC who underwent fractionated
iodine 125 plaque radiotherapy. He had a recurrence approximately 8
months after plaque treatment and subsequently underwent enucleation
of the right eye. Clinical follow-up examinations revealed no further
recurrence at 17 months. Patient 3 is a 40-year-old woman treated for
right MCC with carbon dioxide laser with recurrence at 3 weeks. She
subsequently underwent radiation treatment with the development of
regional lymph node metastases 16 months later. CONCLUSIONS: MCC is a
rare neoplasm that displays an extraordinary capacity for aggressive
local invasion. This series of three case reports demonstrates the
high recurrence rate of MCC and the response of this tumor to
different current modalities of treatment. Extended follow-up is
required with this tumor because distant metastases can occur very
late.
Intraocular neoplastic cyst
from mucoepidermoid carcinoma of the conjunctiva.
Arch Ophthalmol. 1998 Nov;116(11):1521-3.
An 89-year-old woman with
recurrent conjunctival mucoepidermoid carcinoma developed intraocular
inflammation and an elevated fundus lesion that simulated choroidal
detachment in her affected right eye. Intraocular invasion of squamous
cell carcinoma was suspected and the eye was enucleated. Pathologic
examination of the enucleated eye showed intraocular invasion by
conjunctival mucoepidermoid carcinoma that formed a suprauveal cyst
lined with malignant epithelial cells. The patient developed an
orbital recurrence 1 year later and underwent orbital exenteration.
She died 2 years later from an unrelated cause. Conjunctival
mucoepidermoid carcinoma can exhibit intraocular invasion and produce
an intraocular neoplastic cyst.
Mucoepidermoid carcinoma of
the epibulbar connective tissue with diffuse intraocular epithelial
invasion. Klin
Monatsbl Augenheilkd. 1995
Oct;207(4):264-5.
PATIENT: A 55-year-old man was
treated twice with local excision and crycoagulation for a recurrent
limbal mass of the left eye. The original histologic diagnosis was
squamous cell carcinoma. Three months after the last recurrence the
globe was enucleated because of a spontaneous perforation at the
corneoscleral limbus with iris prolapse. Histologic examination,
including PAS and mucicarmine stains, revealed a mucoepidermoid
carcinoma of the epibulbar conjunctiva with infiltration of the
cornea, sclera, iris and ciliary body. CONCLUSIONS: Examination of
specially stained sections (e.g. with mucicarmine) should be routinely
performed for those conjuctival neoplasms that contain a squamous
component. Aggressive surgical management, such as early enucleation
including normal appearing tissue next to the globe, should be
considered for treatment of primary mucoepidermoid carcinoma to avoid
later exenteration or metastasis.
Mucoepidermoid carcinoma of
the conjunctiva.Ophthal
Plast Reconstr Surg. 1994
Sep;10(3):163-8.
Mucoepidermoid carcinoma of
the conjunctiva (MECa) is a rare neoplasm. It resembles squamous cell
carcinoma (SCCa), clinically and histologically. Nevertheless, it is
characterized by a high degree of local aggressiveness. We reviewed
all cases of MECa reported in the English literature for
epidemiological data, characteristics of the tumor, treatment, and
outcome. We found that MECa, reported predominantly in aging males
(median age 71 years), arises in the limbal and perilimbal areas.
Simple excision is followed by rapid recurrence, and most tumors will
require enucleation or exenteration for local control. Histological
stains directed to the production of mucin are essential for the
diagnosis. The recommended treatment is wide local excision.
Enucleation or exenteration is recommended for tumors invading the
globe or orbit.
Mucoepidermoid carcinoma of
the conjunctiva with intraocular invasion. Apropos of a case.J
Fr Ophtalmol. 1991;14(5):349-52.
One case of mucoepidermoid
carcinoma of the conjunctiva with intraocular invasion is described.
Review of literature retrieve 15 cases of conjunctival localisation of
mucoepidermoid carcinoma. These tumors appear to be locally
aggressive, they all invade the intraocular or intraorbital
structures. They require always a radical surgery with wide excision.
Histopathologically, histochemical stains for glycoproteins confirm
the diagnosis with admixture of squamous and mucus secreting cells.
Mucoepidermoid carcinoma of
the conjunctiva: report of a case in a 36-year-old with paranasal
sinus invasion.Ophthalmic
Surg. 1986 Mar;17(3):151-4.
Mucoepidermoid carcinoma is a
rare, highly invasive tumor of the conjunctiva that occurs in elderly
persons. Although clinically indistinguishable from squamous cell
carcinoma, mucoepidermoid carcinoma is more likely to recur following
excision and to invade the eye. The following case report describes a
36-year-old man with mucoepidermoid carcinoma of the right caruncle
that invaded orbit, paranasal sinuses, and nasal cavity. The patient
is the youngest person known to have had this tumor, and represents
the first reported case in which mucoepidermoid carcinoma of the
conjunctiva has extended beyond the orbit. This case emphasizes the
importance of prompt and adequate primary treatment.
Mucoepidermoid carcinoma of the
conjunctiva.Arch
Ophthalmol. 1984 May;102(5):730-1.
A 73-year-old man had a limbal
nodule that, on histopathologic examination, proved to be
mucoepidermoid carcinoma of the conjunctiva. Despite radiation therapy
and extensive corneoscleral lamellar resection, widespread invasion of
the lids and orbit ultimately led to exenteration. Although
mucoepidermoid carcinoma of the conjunctiva resembles squamous cell
carcinoma clinically and histopathologically, it pursues a more rapid
and destructive clinical course. Intraepithelial invasion often leads
to tumor involvement of conjunctiva and skin that seem normal on
clinical examination. Special stains and a high level of suspicion are
required for diagnosis of mucoepidermoid carcinoma of the conjunctiva,
and proper initial management demands more aggressive surgical
resection than is usually indicated for squamous cell carcinoma.
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