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Benign clear (sugar)
cell tumor of the lung with CD1a expression.Pathol
Int. 2006 Aug;56(8):453-6.
Reported
herein is a case of benign clear cell tumor of the lung in a
60-year-old man. Chest X-ray and CT examination revealed an abnormal
nodule with homogenous density and a clear margin in the lower lobe of
the left lung. The resected tumor was 13 mm in size,
well-circumscribed and was graysh-white on cut surface. Histological
examination showed a diffuse growth pattern of polygonal tumor cells
with indented and pleomorphic nuclei, and clear abundant cytoplasm
with a distinct cell border surrounded by thin-walled vascular spaces
and sinusoid-type vessels. The clear cytoplasm contained numerous
glycogen granules as demonstrated by PAS staining. In the present case
there was focal immunoreactivity for S-100 protein, HMB-45,
neuron-specific enolase, cathepsin B and melan A, which are consistent
with reported immunohistochemical staining patterns of benign clear
cell tumor. Based on these findings, the tumor was diagnosed as a
benign clear cell tumor of the lung. Although most clear cell tumors
are considered to belong to the family of neoplasms with perivascular
epithelioid cell differentiation (PEComas), histogenesis of benign
clear cell tumor of the lung has remained unclear. This first report
of CD1a expression in this tumor might provide a new insight into its
histogenesis and diagnosis.
Clear cell
tumor of the lung.
Int J Clin Oncol. 2006 Dec;11(6):475-7.
Clear cell
tumor of the lung is a rare benign tumor. We report herein a case of
clear cell tumor of the lung. A 45 year-old woman with a round mass
lesion of approximately 2 cm diameter on chest X-ray underwent a
thoracotomy. Pathologic examination revealed sheets of large round or
polygonal cells with clear cytoplasm and immunoreactive positivity for
HMB-45 and vimentin. Investigation with abdominal CT scans showed no
evidence of renal disease, and the tumor was diagnosed as clear cell
tumor of the lung.
The "sugar"
clear cell tumor of the lung-clinical presentation and diagnostic
difficulties of an unusual lung tumor in youth.J
Pediatr Surg. 2006 Jun;41(6):e27-9.
A case of the
"sugar" clear cell tumor of the lung in a 16-year-old boy is
presented. The course of the disease with general symptoms, never
reported before, highlights diagnostic difficulties of an extremely
rare lung tumor in youth. The boy presented with daily spikes of
unexplained high fever of 6 weeks' duration with features of
hypochromic microcytic anemia, elevated erythrocyte sedimentation
rate, C-reactive protein, alpha(2)- and beta-globulins, and elevated
platelet count. The lung tumor was a yellow, circumscribed mass
confined to the sixth segment of the left lung. Histological
examination revealed the tumor composed of cells with clear cytoplasm
with large content of glycogen, with no signs of necrosis, and
immunoreactive for HMB-45, but not for cytokeratin, LCA, CD34, and
CD68. The performed thoracotomy and segmentectomy were both diagnostic
and curative.
Clear cell tumor of the lung. A case report with review of the
literature.Rev
Pneumol Clin. 2006 Dec;62(6 Pt 1):395-8.
Clear-cell
tumor of the lung is a rare entity of unknown etiology and
histogenesis. This neoplasm typically presents as an asymptomatic,
peripheral, sharply rounded mass in the lung, and histologically
composed of large cells with a clear cytoplasm rich in glycogen,
blended with an abundant network of sinusoid-type vessels.
Immunohistochemical and ultrastructural procedures lead to diagnosis.
We describe a primary pulmonary clear cell "sugar" tumor observed in a
28-year-old woman, and give a review of the literature. Clinical
aspects, differential diagnosis, therapy and histogenetic aspects are
discussed.
Clear cell tumor of the lung.Pathologe.
2005 Sep;26(5):378-82.
Clear cell tumors
of the lung are rare tumors composed of epithelioid HMB45 positive
tumor cells. It has been proposed that clear cell tumors generate from
perivascular epithelioid cells which are also found in renal
angiomyolipoma. Due to its morphologic epithelioid features with clear
cytoplasm the distinction from either primary or metastatic clear cell
carcinoma is difficult. Usually clinical investigations do not lead to
the final diagnosis so that only subsequent histological examination
and immunophenotyping can establish the correct tumor classification.
We describe the case of a 52 year old woman who underwent exploratory
thoracotomy because of a lung mass in the right lower lobe. In frozen
sections a solid trabecular tumor was diagnosed, paraffin histology
and immunohistochemistry revealed a clear cell tumor of the lung. The
difficulty of the correct diagnosis of the clear cell tumor of the
lung in frozen sections is discussed as well as the differential
diagnosis.
A
rare cause of hemoptysis: benign sugar (clear) cell tumor of the lung.Eur
J Cardiothorac Surg. 2004 Apr;25(4):652-4.
A case of benign
sugar (clear) cell tumor of the lung with an unusual clinical
presentation and its evaluation with computed tomography are reported.
A 48-year-old man presented with one episode of hemoptysis. Chest
radiographs revealed a round nodule in the lower left lung lobe, and
fiberoptic bronchoscopy was normal. On the computed tomography scans,
the nodule showed intense post-contrast enhancement (74.7 Hounsfield
units). The patient underwent a left thoracotomy, and a segmentectomy
was performed. Pathologic examination showed a benign sugar cell tumor
of the lung. The patient is alive and has remained free of disease for
the last 2 years. To the best of our knowledge, this is the first case
report of sugar cell tumor located in lung parenchyma that presented
with hemoptysis and the second report of the contrast-enhanced
computed tomography findings in this neoplasm.
Sugar tumor of the
lung--case report and review of the literature.Chirurg.
2003 Jul;74(7):683-6.
Clear
cell tumors of the lung are commonly primary, clear-cell, bronchial
carcinomas or metastasis of a renal cell carcinoma. Compared to this,
pulmonary sugar tumor is a rare entity. A large intracellular content
of glycogen and immunohistochemical procedures lead to diagnosis. The
demonstration of the premelanosomal protein HMB-45 is considered as
proof, but this is not airtight. We present a case of metachronic,
benign, and HMB-45-negative sugar tumor of the lung after
hypernephroma and give a review of the literature.
Benign clear cell
tumor of the lung.Ultrastruct
Pathol. 2001 Nov-Dec;25(6): 479-83.
A 49-year-old
woman presented with a solitary pulmonary nodule in the right lung.
The tumor was well circumscribed and showed a reddish brown cut
surface. It showed a diffuse growth pattern of polygonal cells with
clear abundant cytoplasm and distinct cell border around thin-walled
vascular spaces and sinusoid-type vessels. Based on morphological
findings, the patient was diagnosed as having benign clear cell tumor
of the lung. Silver impregnation and PAM stains showed fine reticular
fibers continuously surrounding the vessels and individual neoplastic
clear cells. Strong immunostaining for type IV collagen was observed
surrounding all the individual clear cells. A few clear cells were
positive for HMB-45 and NCAM 123C3 (CD56). Electron microscopically,
clear cells had numerous membrane-bound glycogen granules and a large
amount of non-membrane-bound glycogen. The neoplastic cells were
surrounded by external lamina and cytoplasmic processes. The
neoplastic clear cells showed morphologic features seen in pericytes,
melanocytic cells, and neuroendocrine cells.
Benign clear cell
tumor of the lung (sugar tumor). Morphologic, immunohistochemical and
ultrastructural evaluation.Pneumonol
Alergol Pol. 2000;68(1-2):60-4.
Clear cell tumour
or "sugar tumour" of the lung is a rare primary neoplasm with unique
histologic and electron microscopic features that may resemble those
of metastatic renal cell carcinoma. An immunohistochemical studies are
useful in a differential diagnosis these tumours: HMB45 in combination
with a panel of various antibodies. The authors present a benign clear
cell tumour of the lung, diagnosed on the base of its morphological,
immunohistochemical and ultrastructural features.
Clear-cell tumor of the lung: description of a case 1 mm in diameter
("micro-sugar tumor") .Pathologica.
2001 Oct;93(5):556-60.
Clear cell
("sugar") tumour of the lung is a rare neoplasm, generally presenting
as a discrete nodule on the chest X-ray. We report a case of clear
cell tumour of the lung in a 64-year-old woman. The tumour at
presentation was 1 mm in diameter.
Clear cell tumor of the
lung: an immunohistochemical and ultrastructural study supporting a
pericytic differentiation.Mod
Pathol. 1997 Oct;10(10): 1001-8.
Clear cell tumor
("sugar tumor") of the lung is a rare benign lesion with unclear
histogenesis. It is composed of large cells with a clear cytoplasm
rich in glycogen, blended with an abundant network of sinusoid-type
vessels. We report two cases of sugar tumor, one of these lacking
clearly demonstrable glycogen storage. In both, the tumor cells lacked
keratin expression and were positive for vimentin and HMB 45, an
antibody recognizing perivascular or myoid cell proliferation such as
lymphangioleiomyomatosis and angiomyolipoma. The tumor cells were also
immunoreactive for an endothelial cell marker, CD 34, but negative for
Factor VIII or smooth muscle actin. Intercellular deposition of
basal-like material was immunostained with Type IV collagen. At
ultrastructural examination of one of these cases, tumor cells showing
features of pericytes or poorly differentiated perivascular
leiomyocytes encased in basement material were observed in close
association with endothelial cells; their cytoplasm contained numerous
membrane-bound glycogen and pinocytic vesicles. We conclude that on
the basis of immunohistochemical and ultrastructural phenotype, sugar
tumor presents pericytic features and that glycogen storage is not a
constant feature of these benign tumors.
Clear cell tumor of the
lung: immunohistochemical and ultrastructural evidence of
melanogenesis. Am J Surg Pathol 1991;15:644–653.
Clear cell tumors
of the lung (CCTL) are rare neoplasms of uncertain differentiation. A
previous study of eight CCTL demonstrated a lack of epithelial
features, but their exact nature remained unknown. In the current
study of nine CCTL, immunohistochemistry using preliminary enzymatic
digestion showed strong reactivity with the antimelanocytic markers
HMB-45 (seven cases) and HMB-50 (six cases) and focal positivity for
S-100 (nine cases), neuron-specific enolase (three cases),
synaptophysin (one case), and Leu-7 (one case). Staining for
cytokeratin, epithelial membrane antigen, chromogranin, and glial
fibrillary acid protein was uniformly negative. Frozen-section
immunoreactivity for vimentin and the antimelanocytic monoclonal
preparation NKI/BETEB was noted in the one CCTL for which snap-frozen
tissue was available. Ultrastructural examination of three
glutaraldehyde-fixed CCTL showed rare neoplastic cells containing the
full spectrum of melanosomes in two, one of which also contained
neurosecretory-type granules. Aberrant melanosomal forms were
identified in the third case. Melanosomes were not identified in the
remaining five CCTL studied from formalin- or paraffin-retrieved
material. The findings indicate that CCTL exhibits melanocytic
differentiation. This feature may be of considerable value in
distinguishing CCTL from other clear cell neoplasms.
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