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Recurrent ceruminous adenocarcinoma of the external auditory canal.:
ORL J Otorhinolaryngol Relat Spec. 2003 Sep-Oct;65(5):300-2.
Ceruminous
adenocarcinoma is a rare malignant neoplasm of the glandular
structures of the external auditory canal. The true incidence and
behavior of these rare tumors are still unclear due to confusing
terminology, classification and histological definitions. Therefore,
the ENT surgeon faces major difficulties in choosing the method of
management- conservative or more radical surgery--with the addition or
not of radiotherapy. We report a 57-year-old male patient with a
recurrence of a previously excised (maybe partially) and irradiated ceruminous adenocarcinoma of the right external auditory canal.
Aggressive surgery was considered as the treatment of choice. However,
the patient refused this approach and, as a consequence, a
conservative excision was performed but with histologically confirmed
healthy margins. To our surprise, the patient showed an excellent
response and he is disease free 3 years following the last operation.
Although recurrences usually occur within months after inadequate
management, some may happen even 7 years post treatment. Therefore,
routine long-term follow-up was advised.
Glandular neoplasms
of the external auditory canal--clinical and morphologic observations. Otolaryngol
Pol. 2003;57(1):51-7.
In the article
cases of glandular neoplasms of the external auditory canal were
presented. Ceruminous adenoma was diagnosed in three persons, adenoid
cystic carcinoma--in three patients and ceruminous adenocarcinoma in
one patient. All of them were treated surgically or by combined method
with radiotherapy. Difficulties with exact histopathological diagnosis
and with choice of a method of treatment were stressed. Classification
of the glandular neoplasms of the external auditory canal was also
presented underlying a histopathological and clinical diversity of
these tumors, which had previously been incorrectly qualified in one
group ceruminoma.
Tumors of the
ceruminous glands. Ann
Pathol. 1995;15(2):147-9.
Tumors of
ceruminous glands, called "ceruminoma" are rare. They arise from the
ceruminous glands of the external auditory canal. They realise a group
of glandular tumors diversified in histologic pattern and prognosis.
Three patients with ceruminous gland tumors are reported: one case of
ceruminous adenoma, one case of adenocarcinoma and adenoid cystic
carcinoma in the third one.
Adenocarcinoma of
ceruminous glands. Ultrastructural, immuno histochemical and lectin
histochemical studies. Acta
Morphol Hung. 1991;39(2):157-65.
A case
of ceruminous adenocarcinoma is reported. The tumor destroyed the
right pyramid, widely invaded the base of the skull and caused death
shortly after the diagnosis. Distant metastases were not found by
autopsy. The tumour cells reacted with epithelial markers and with the
antibody against S-100 protein. Heparan sulphate proteoglycan seemed
to be a good marker for detecting basement membrane ruptures and
concomitant tumour invasion. Among the lectins BS-I and PNA gave the
strongest reactions in the stroma. This is the first
immunohistochemical and lectin histochemical report on ceruminous
adenocarcinoma.
Ceruminous
adenocarcinoma: report of a case.Rev
Med Univ Navarra. 1990
Jul-Sep;34(3):135-7.
A case of an adenocarcinoma of ceruminous glands located on the
external auditory meatus is presented. It must be noted the
discrepancy between the well-differenciated histologic appearance and
the markedly aggressive clinical course.
Ceruminoma
with intracranial invasion- case report.Neurol
Med Chir (Tokyo). 1990 Dec;30(13):1034-7.
Ceruminous
gland tumors (ceruminomas), which usually involve the external
auditory canal, are rare. A case of ceruminoma invading the temporal
bone and histologically proven to be papillary adenoma is presented.
The tumor recurred and invaded intracranially after subtotal removal
and was finally diagnosed as adenocarcinoma. The importance of early
diagnosis and radical treatment is stressed.
Tumors of the
ceruminous glands.Laryngol Rhinol Otol (Stuttg). 1987
Sep;66(9):465-8.
Tumours
originating from the ceruminous glands can be classified into five
types: adenomas, adenocarcinomas, adenoid-cystic carcinomas,
pleomorphic adenomas and mucoepidermoid carcinomas. The diagnosis is
based on histological findings and can be quite difficult if the
tumour status has to be determined. Classification into one of the
five types of tumours may be facilitated at times by studying the
clinical pattern. Three case reports are quoted as examples to
illustrate that neoplasias originating from the ceruminous glands can
assume considerable proportions and must be considered in differential
diagnosis when assessing space-occupying growths in the soft tissue of
the neck. Whereas prognosis of adenomas and pleomorphic adenomas can
be considered to be good, it must be regarded as likely to be infaust
in the case of adenocarcinomas, adenoid-cystic carcinomas and
mucoepidermoid carcinomas. The use of cytostatics resulted in a marked
reduction of the tumour in one of the described cases of
adenocarcinoma.
Tumors of
ceruminous glands. J
Am Acad Dermatol. 1984;11(5 Pt 1):841-7.
Tumors
of the ceruminous glands may involve the auricular and preauricular
skin and thus should be included in the differential diagnosis of
neoplasms involving these areas. A rational decision as to the
management of ceruminous gland tumors depends on the precise
histologic classification of these tumors and the extent of
involvement. We present seven patients with tumors of the ceruminous
glands: ceruminous adenoma in one, ceruminous adenocarcinoma in three,
and adenoid cystic carcinoma in three. The literature is reviewed with
respect to signs and symptoms, pathology, and therapy.
Intracranial
ceruminous gland adenocarcinoma. J
Neurosurg. 1981;55(6): 952-6.
Patients with
adenocarcinoma of the ceruminous gland arising in the middle ear have
a typical syndrome consisting of unilateral hearing loss, otalgia,
facial paresis, and a middle-ear mass. Adjacent cranial nerves also
may be affected. Some patients may have an ipsilateral cerebellar
ataxia if the lesion extends into the cerebellopontine angle and
compresses the cerebellar hemisphere. Obstructive hydrocephalus may
occur secondary to obstruction of the aqueduct or fourth ventricle.
The initial clinical findings may be those of a jugular foramen
syndrome. These lesions are usually slow-growing and may be associated
with a very prolonged clinical course. Although the tumors are rare,
the physician should be aware of their existence if proper care is to
be given.
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