Truly benign "bronchial adenoma". Report of 10
cases of mucous gland adenoma with immunohistochemical and
ultrastructural findings.
Am J
Surg Pathol. 1995 Aug;19(8):887-99.
Mucous
gland adenoma of the bronchus (MGAB) is a rare, solitary,
benign, well-circumscribed, multicystic, predominately exophytic
bronchial tumor. Mucous gland adenoma arises from the submucosal
seromucous glands and ducts of proximal airways; since the
location, signs and symptoms, and bronchoscopic findings are
similar to those of other tumors arising in the bronchus,
diagnosis depends on tissue biopsy. We herein report 10 patients
with MGAB. Patients ranged in age from 25 to 67 years old (mean,
52). In two thirds of patients, the tumor was located in the
middle or lower lobes. Tumors ranged in size from 0.8 to 6.8 cm
(mean, 1.8). Cut surface was shiny, mucoid, cystic, and usually
firm. Mucous gland adenomas are protean in their histologic
patterns. They may appear glandular and tubulocystic or
papillocystic, and they often show a mixture of these features.
The tumors are rich in mucins and are immunopositive for
epithelial markers. Mucous gland adenoma needs to be
distinguished from low-grade malignant tumors of the
bronchus--most notably, low-grade mucoepidermoid carcinoma.
Complete removal of the tumor is curative.
Pathology of seven
mucous cell adenomas of the bronchial glands with particular
reference to ultrastructure.Histopathology.
1985 Jul;9(7):687-701.
The
pathology, including ultrastructure, of seven mucous cell
adenomas of the bronchial glands is described. They occurred as
polypoid intraluminal lesions in both male and female patients
between the ages of 7 and 55 years (mean 26 years).
Histologically they were all benign and consisted of
predominantly mucus-secreting cells arranged in acini or ducts
or in solid groups. A little squamous differentiation was
evident in four cases, insufficient in our opinion, to justify
the term mucoepidermoid tumour. By electron microscopy, many
tumour cells resembled mucous cells of the bronchial glands,
containing typical large mucous granules of finely granular,
reticular or fibrillated material, and sometimes small
electron-dense bodies. In four cases some cells showed both
secretory granules and features of squamous differentiation such
as numerous tonofilaments and desmosomes. Oncocytic
differentiation was seen occasionally.
Pure bronchial
adenoma. Anatomico-clinical and ultrastructural study of a case.Ann
Pathol. 1987;7(4-5):315-9.
We report a
case of monomorphic bronchial cystadenoma (or mucous gland
adenoma). This exceptional tumor (only 34 cases reported up to
now) is benign, but a lobectomy is often necessary because of
severe inflammatory lesions of the surrounding lung.
Ultrastructurally it was different from the other tumors of
bronchial glands, since it contained mucous cells, myoepithelial
cells, and oncocytic cells, and the basement membrane was
thickened.
Mucous gland adenoma
of the bronchus.South
Med J. 1979 Jan;72(1):83-5.
Mucous
gland adenoma of the bronchus is a truly benign bronchoid
neoplasm which responds to simple surgical excision, sparing as
much functional lung tissue as possible. The patient here
reported is well one year after such treatment.
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