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Alveolar adenoma.J
Bras Pneumol. 2006 May-Jun;32(3):267-9.
Alveolar
adenoma is a rare benign neoplasm of the lungs, and very few cases
have been described in the literature. Patients with alveolar
adenoma are frequently asymptomatic and are diagnosed through the
accidental discovery of a singular, well-delineated nodule on a
routine chest X-ray. The definitive diagnosis is made histologically,
and the treatment consists of surgical resection of the nodule.
Alveolar
adenoma of the lung: a clinicopathological description of a case of
this very unusual tumour.J
Clin Pathol. 2005 Nov;58(11):1211-4.
Alveolar adenomas are extremely rare, and are probably benign lung
tumours of unknown histogenesis. This report describes a case of
alveolar adenoma in a 43 year old white man, who presented with
pleuritic chest pain. A chest x ray and computerised tomography scan
demonstrated a solitary left lower lobe lung nodule. Although a
positron emission tomography scan seemed to document the benign
nature of the lesion, a thoracoscopic wedge resection was performed
to alleviate the symptoms and verify the diagnosis. Histologically,
the lesion was well demarcated, dominated by large and small cysts
with no normal lung parenchyma. The interstitial cellular component
consisted of both epithelioid and vaguely spindle shaped cells. The
cystic cell linings were mostly indistinct, although areas of
cuboidal epithelial cells were seen. Multiple histochemical and
immunohistochemical tests were performed. There were no histological
signs of malignancy and the patient is doing well one and a half
years postoperatively.
Alveolar
adenoma of the lung: computed tomography and magnetic resonance
imaging findings.
J Thorac
Imaging. 2002 Apr;17(2):163-6.
Alveolar
adenoma of the lung is a rare benign neoplasm with distinctive gross
and microscopic findings. Radiographically, alveolar adenoma usually
presents as a well-circumscribed, peripheral, solitary nodule. The
authors describe the contrast-enhanced computed tomography and
magnetic resonance imaging features of alveolar adenoma of lung.
Magnetic resonance imaging demonstrated the presence of a cystic
space with central fluid and thin-rim enhancement. These findings
are suggestive of a benign nodule, and alveolar adenoma of lung
should be added to the differential diagnosis of nodules that
demonstrate this pattern of enhancement and are probably benign.
Pulmonary
nodule caused by an alveolar adenoma of the lung.Virchows
Arch. 1997 Feb;430(2):181-4.
Alveolar
adenomas of the lung may be a rare cause of solitary coin lesions on
chest radiographs. We report a case of this neoplasm, describe its
morphological and immunohistochemical characteristics and give
further evidence that alveolar adenomas of the lung represent a
benign proliferation of both the alveolar epithelium and the septal
mesenchyme.
Alveolar
adenoma.
Ann Thorac Surg. 2004 Nov;78(5):1842-3.
Alveolar
adenoma of the lung is a rare benign neoplasm with proliferation of
alveolar epithelium and septal mesenchyme. This unusual neoplasm
presents as a solitary mass on chest roentgenograms, especially in
older, asymptomatic patients. We report a case of this unusual
neoplasm and describe the histologic and radiographic features of
this tumor, which should be included in the differential diagnosis
of a solitary pulmonary mass.
Alveolar
adenoma: a histochemical, immunohistochemical, and ultrastructural
analysis of 17 cases.
Hum Pathol. 1999
Feb;30(2):158-67.
Alveolar
adenoma of lung is a rare benign neoplasm of uncertain histogenesis.
Its rarity hampers characterization of its epithelial and
mesenchymal elements. Clinical and histopathologic features of 17
alveolar adenomas were reviewed. Histochemistry was performed on 10
cases, ultrastructural analysis on two, and immunohistochemistry on
six cases for pneumocyte markers, thyroid transcription factor
(TTF-1), surfactant protein markers pro-SP-B and pro-SP-C, and the
Clara cell marker, CC10. Immunohistochemistry was performed in nine
cases for desmin, smooth muscle actin, muscle-specific actin,
cytokeratin, proliferating cell nuclear antigen (PCNA), factor VIII,
and carcinoembryonic antigen. The mean age was 53 years. Seven cases
occurred in men, and nine occurred in women. The age and sex were
not known for one patient. The tumors were coin lesions on chest
radiographs in asymptomatic patients except for one (cough). The
mean size was 2.2 cm. The tumors were well demarcated with multiple
cystic spaces containing granular material. Mostly type 2
pneumocytes lined the cystic spaces with fewer type 1 cells and no
Clara cells. This was confirmed by staining for TTF-1, pro-SP-B, and
pro-SP-C and by ultrastructure. CC10 was negative in all cases. The
stroma varied from prominent spindle cells with a myxoid matrix to
thin alveolar septa. The interstitial spindle cells resembled
fibroblasts by immunohistochemistry and ultrastructure. Follow-up
data available in five cases showed no recurrence at 2, 2, 5, 8, and
13 years. In summary, alveolar adenoma is a benign neoplasm
consisting of an intimate admixture of alveolar epithelial and
septal mesenchymal tissue. Most of the epithelial cells are type 2
pneumocytes, and the interstitial stromal cells are fibroblasts or
fibroblast-like cells. Recognition of its characteristic
morphological appearance allows for its distinction from other
benign lesions of the lung.
Alveolar
adenoma.
Hum Pathol. 1986 Oct;17(10):1066-71.
This report
describes six cases of an unusual pulmonary neoplasm, the alveolar
adenoma, that consists of a benign proliferation of alveolar
epithelium and septal mesenchyme. The neoplasm presents as a
solitary peripheral lesion on chest radiographs, particularly in
older patients. It has unique histologic features, which should be
distinguished from those of sclerosing hemangioma, lymphangioma, and
bronchioloalveolar carcinoma.
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