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Immunocytochemical characterization of lung tumors in fine-needle
aspiration. The use of cytokeratin monoclonal antibodies for the
differential diagnosis of squamous cell carcinoma and adenocarcinoma.
Cancer. 1990 Oct 15;66(8):1817-27.
In the current
study, immunocytochemical typing of intermediate filaments was used
for a differential diagnosis of human lung tumors from transthoracic
fine-needle aspiration biopsies (TFNAB). The authors have compared the
cytologic diagnosis of 53 lung cancer cases with the
immunofluorescence patterns obtained using a panel of monoclonal
antibodies, five of which (KG 8.13, KM 4.62, Ks B.17, KS 8.12, KK
8.60) react with specific cytokeratin polypeptides and one with
vimentin (VIM 13.2). Only in six of 23 samples cytologically diagnosed
as squamous cell carcinoma did the immunocytochemical typing of
cytokeratins (ICTC) confirm the cytologic diagnosis. In seven cases
some of the tumor cells stained positively with antibody Ks B.17
specific for simple epithelial keratin (No: 18), suggesting the
presence of some cells of glandular origin. In ten additional cases
the ICTC was in conflict with the cytologic diagnosis of squamous cell
carcinoma (i.e., antibodies Ks 8.12 and KK 8.60 were negative, and
antibody Ks B.17, positive) supporting a diagnosis of adenocarcinoma.
In 14 of 18 cases cytologically diagnosed as adenocarcinoma, the ICTC
confirmed the diagnosis whereas in four cases additional presence of
some squamous cells was noticed. The ICTC labeling of cases
cytologically diagnosed as undifferentiated and large cell carcinomas
was similar to that of the group of adenocarcinomas. Thus, the
application of cytokeratin typing for TFNAB samples seems to provide a
vital complementation to routine cytologic study, especially for cases
cytologically diagnosed as squamous carcinoma.
Pulmonary fine
needle aspiration cytopathology. A five-year correlation study.Acta
Cytol. 1984 Jan-Feb;28(1):72-6.
Transthoracic
fine needle aspiration specimens with abnormal cytology were obtained
from 272 patients between 1976 and 1980 at the University of Rochester
Medical Center. A comparison was made between the original specific
cytologic and final histologic diagnoses on 116 patients; an
additional 16 patients with the cytologic diagnosis of small-cell
carcinoma were evaluated by clinical criteria. Analysis of the data
indicated that malignant neoplasms were identified correctly with an
accuracy of 99%. There was a single false-positive diagnosis.
Predictive values for a specific morphologic variant of pulmonary
neoplasm were 70% for squamous-cell carcinoma, 86% for adenocarcinoma
and 95% for small-cell carcinoma. The probable bases for diagnostic
error are discussed. Confidence intervals calculated from these data
compared favorably with those in recently reported studies. The
results reconfirmed the value of fine needle aspiration cytopathology
for the diagnosis of pulmonary neoplasms.
Well-differentiated fetal adenocarcinoma of the lung: cytomorphologic
features on fine-needle aspiration with emphasis on use of beta-catenin
as a useful diagnostic marker.Diagn
Cytopathol. 2007 Jan;35(1):39-42.
Well-differentiated fetal adenocarcinoma (WDFA), also known as low
grade adenocarcinoma of the fetal lung type, is a rare pulmonary
neoplasm now considered to be a variant of lung adenocarcinoma rather
than a type of pulmonary blastoma. Upregulation of the Wnt signaling
pathway with subsequent aberrant nuclear/cytoplasmic beta-catenin
expression has been recently described in these tumors providing a
possible pathogenetic role for this gene in WDFA. We describe the
cytomorphologic findings of a case of WDFA in a 36-yr-old female
patient and emphasize the diagnostic utility of aberrant nuclear/cytoplasmic
expression of beta-catenin as an adjunct to the correct preoperative
recognition of this tumor on aspiration cytology.
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