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Clear
cell "sugar" tumour of the pancreas is an extremely rare tumour
which resembles
clear cell 'sugar' tumour
of the lung.
Visit:
Pancreatic Pathology Online
;
Exocrine Pancreatic Tumours
;
Clear cell sarcoma & PEComas
.
Gross features:
Well-demarcated nodular lesion.
Microscopic
features:
The resected tumour consist of a population of
large epithelioid
cells with clear or eosinophilic, granular cytoplasm,
rich in glycogen,
with nuclear pleomorphism and there is no mitotic
activity.
The epitheloid cells with clear cytoplasm
are grouped around
sinusoidal vessels.
The
immunostaining pattern resemble those described in clear cell
"sugar" tumour of
the lung i.e. immunoreactivity with
melanoma
associated antigen HMB-45 and actin.
The tumour cells are negative for
cytokeratin, NSE, chromogranin A,
lipase, amylase.
Tumour arises
from perivascular epithelioid cells, which also cause
lymphangioleiomyomatosis
and
angiomyolipoma .
Differential diagnosis:
Clear cell
carcinoma of the Pancreas
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