Pancreatic Pathology Online

Pathology of Clear cell 'sugar' tumour of the Pancreas      

Dr Sampurna Roy MD   


Clear cell 'sugar' tumour of the pancreas is an extremely rare tumour which resembles clear cell 'sugar' tumour of the lung.  

Visit : Exocrine Pancreatic Tumours ; Clear cell sarcoma and PEComas.

Gross features:  Well-demarcated nodular lesion.

Microscopic features: The resected tumour consist of a population of large epithelioid cells with clear or eosinophilic, granular cytoplasm, rich in glycogen, with nuclear pleomorphism and there is no mitotic activity.




The epitheloid cells with clear cytoplasm are grouped  around sinusoidal vessels. 

The immunostaining pattern resemble those described in clear cell  "sugar" tumour of the lung i.e. immunoreactivity with melanoma associated antigen HMB-45 and actin.

The tumour cells are negative for cytokeratin, NSE, chromogranin A, lipase, amylase.

Tumour arises from perivascular epithelioid cells, which also cause lymphangioleiomyomatosis and angiomyolipoma.

Differential diagnosis: Clear cell carcinoma of the Pancreas




Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)






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