Pancreatic Pathology Online

Pathology of Clear Cell Carcinoma of the Pancreas    

Dr Sampurna Roy MD              

 

Clear cell carcinoma has been found in various organs, few cases of cases have been reported in the pancreas.

The cytoplasmic vacuoles in these clear cells contain glycogen and a variable amount of mucin but no fat.

Histologically, the pancreatic tumor was predominantly composed of clear cell nests with scanty fibrous stroma and scattered duct-like structures.

Neither clear cell nor duct-like components of the tumor showed mucin production. 

According to one study the immunohistochemical stains showed positive reactions to antibodies against pan-cytokeratin, cytokeratin 7, carcinoembryonic antigen (CEA) and epithelial membrane antigen (EMA).

On the other hand, there was a negative reaction for cytokeratin 20, chromogranin, synaptophysin, smooth muscle actin and HMB-45.

Differential diagnosis :  Metastatic carcinoma from carcinoma of the kidney or adrenal gland.

 Visit: Metastatic tumours of the Pancreas

 

Further reading:

Clear cell carcinoma of the pancreas--a case report and review of the literature.

Clear cell carcinoma of the pancreas: an adenocarcinoma with ductal phenotype.

Clear cell "sugar" tumor of the pancreas. A novel member of the family of lesions characterized by the presence of perivascular epithelioid cells.

Differential expression of CD44 splice variants in human pancreatic adenocarcinoma and in normal pancreas.

Clear cell endocrine pancreatic tumor mimicking renal cell carcinoma: a distinctive neoplasm of von Hippel-Lindau disease.

Clear cell carcinoma of the pancreas: an adenocarcinoma with unusual phenotype of duct cell origin.

Clear cell ductal adenocarcinoma of pancreas: a case report and review of the literature.

Clear cell carcinoma of exocrine pancreas: a rare tumor with an unusual presentation.

Clear-cell carcinoma of the pancreas in fine-needle aspirate.

Solid type clear cell carcinoma of the pancreas: differential diagnosis of an unusual case and review of the literature.

 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)


 

 

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