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Solid type clear cell carcinoma of the pancreas: differential
diagnosis of an unusual case and review of the literature.Virchows
Arch. 2007 Jun;450(6):719-26.
Pancreatic
neoplasms have been reliably classified on the basis of their
histopathology and immunophenotype. In this study, we report on a
pancreatic tumor whose phenotype and genotype could not be assigned to
any known tumor entity. The tumor was observed in the pancreatic head
of a 54-year-old woman. It was found to be a solid infiltrating
carcinoma with abundant clear cells. Apart from cytokeratin, the tumor
cells expressed vimentin, S100, and MUC-1. DNA microarray analysis
revealed a transcription profile clearly differing from that of normal
pancreatic tissue and pancreatic ductal adenocarcinoma. Despite
metastatic behavior, the tumor displayed a more favorable course than
conventional pancreatic ductal adenocarcinoma. We suggest that this
tumor be called solid type clear cell carcinoma of the pancreas.
Clear cell
carcinoma of exocrine pancreas: a rare tumor with an unusual
presentation.Pancreas.
2005 Mar;30(2):184-5.
Metastatic
clear cell carcinomas are relatively common from primary tumors
arising in the kidney, female genital tract, adrenal cortex, and lung,
but they rarely occur from primary tumors of the pancreas. We report a
case of metastatic pancreatic tumor with marked clear cell changes in
a 46-year-old white man presenting with a pseudocyst of the pancreas.
At laparotomy, there was a hard area in the head of the pancreas and
another hard nodule was present in the omentum. The histologic and
immunohistochemical test of the excised omental nodule exhibited
features consistent with clear cell carcinoma from pancreatic primary.
To our knowledge, this is the first report of a metastatic clear cell
pancreatic tumor with such an unusual presentation.
Clear cell
carcinoma of the pancreas: an adenocarcinoma with unusual phenotype of
duct cell origin.
J Hepatobiliary Pancreat Surg.
2004;11(2):140-4.
Although
clear cell carcinoma has been found in various organs, only six cases
have been reported in the pancreas. Moreover, the histogenesis of
clear cell carcinoma of the pancreas remains controversial. We report
a case of clear cell carcinoma of the pancreas in a 61-year-old woman,
with an unusual pheno- or genotype detected by histochemical,
immunohistochemical, and K- ras oncogene analyses. Histologically, the
pancreatic tumor was predominantly composed of clear cell nests with
scanty fibrous stroma and scattered duct-like structures. Neither
clear cell nor duct-like components of the tumor showed mucin
production. Immunohistochemical analysis of neoplastic cells showed a
positive reaction to antibodies against cytokeratins 8 and 19,
carbohydrate antigen 19-9, and alpha-1-antitrypsin, and showed no
reaction to antibodies against carcinoembryonic antigen,
neuroendocrine markers, trypsin, amylase, and HMB45. K- ras analysis
revealed no mutation at codon 12 in either clear cell or duct-like
components. The patient has had no recurrence as yet. The pancreatic
carcinoma in our patient may be of duct cell origin, but the results
of histochemical, immunohistochemical, and gene analyses and patient's
outcome were unusual compared with those of previous cases.
Pancreatic
metastasis from clear cell renal carcinoma: a clinical case.Chir
Ital. 2002 Nov-Dec;54(6):873-7.
Renal
cell carcinoma rarely metastasizes to the pancreas. In this report we
describe a case of late pancreatic metastases in a seventy-year-old
woman, surgically treated 21 years before for renal clear-cell
carcinoma. Preoperative staging revealed the presence of four
pancreatic lesions. A distal pancreatectomy and splenectomy were
performed, and the postoperative period was complication-free.
Histopathological analysis revealed metastases from renal clear-cell
carcinoma. This case shows that in patients operated on for renal
clear-cell carcinoma we have to consider the possibility of late
metastases to the pancreas. Therefore, these patients should be
submitted to long-term follow-up. In keeping with the current
literature, we advocate aggressive surgical treatment in pancreatic
metastases from renal clear-cell carcinoma.
Clear cell
carcinoma of the pancreas: an adenocarcinoma with ductal phenotype.
Histopathology. 1998 May;32(5):444-8.
AIMS:
Primary clear cell carcinoma of the pancreas resembling metastatic
renal carcinoma has only rarely been described. To date it has been
poorly characterized as a distinct tumour entity. METHODS AND RESULTS:
We report a case of clear cell carcinoma in a 53-year-old man
involving the head of the pancreas and which had a small intraductal
papillary component. The clear cell portion comprised about 90% of the
tumour mass. It showed predominantly a solid growth pattern with a few
scattered tubular structures. Immunocytochemically the tumour cells
stained positively for cytokeratins 7, 8, 18 and 19, whereas the
reaction for vimentin and neuroendocrine markers was negative. K-ras
analysis revealed a point mutation at codon 12 with mutation of GGT to
GAT. CONCLUSION: The intraductal tumour component of this clear cell
carcinoma as well as the cytokeratin pattern and the K-ras mutation
suggest that this rare type of pancreatic cancer has a ductal
phenotype.
An unusual
case of clear-cell carcinoma of the pancreas.
J Chir (Paris). 1994;131(2):86-9.
This case of
clear-cell carcinoma of the pancreas was a rare for three reasons: a)
discovery: the investigation was indicated after sudden digestive
hemorrhage revealed by melena and anaemia; b) morphology: the tumour
began in the head with a spheric tumoural bud and a pediculated
extension into the duodenum; c) pathology a clear-cell tumour similar
to the type seen in renal localizations. Only one other case of such a
primitive tumour was found reported in the literature.
Clear cell
carcinoma of the pancreas.Acta
Pathol Jpn. 1987;37(9):1521-6.
A rare autopsy
case of clear cell carcinoma of the pancreas developing in a
71-year-old Japanese male is described. He complained of epigastralgia
and back pain and was clinically diagnosed as having primary
pancreatic cancer. After death due to disseminated metastasis and
cachexy, autopsy revealed pancreatic clear cell carcinoma
metastasizing to various organs including the lungs (lymphoangiosis
carcinomatosa). The tumor was almost entirely composed of clear cells
with cytoplasm weakly positive for PAS and alcian blue, and negative
for Sudan III stains. Histological differential diagnosis from the
clear cell carcinoma of other organs, especially that of kidney, is
also mentioned.
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