|Pancreatic Pathology Online
Pathology of Clear Cell Carcinoma of the Pancreas
cell carcinoma has been found in various organs, few cases of cases
have been reported in the pancreas.
The cytoplasmic vacuoles in these clear cells contain glycogen and a variable amount of mucin but no fat.
Histologically, the pancreatic tumor was predominantly composed of clear cell nests with scanty fibrous stroma and scattered duct-like structures.
Neither clear cell nor duct-like components of the tumor showed mucin production.
According to one study the immunohistochemical stains showed positive reactions to antibodies against pan-cytokeratin, cytokeratin 7, carcinoembryonic antigen (CEA) and epithelial membrane antigen (EMA).
On the other hand, there was a negative reaction for cytokeratin 20, chromogranin, synaptophysin, smooth muscle actin and HMB-45.
Differential diagnosis : Metastatic carcinoma from carcinoma of the kidney or adrenal gland.
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