Pancreatic Pathology Online
Pathology of Nesidioblastosis
Dr Sampurna Roy MD July 2016
Laidlaw coined the term Nesidioblastosis in 1938 to characterize the
neodifferentiation of the islet cells of Langerhans from pancreatic
Nesidioblastosis is a term that describes multifocal hyperplasia of all pancreatic cell components and is characterized primarily by their disorganization and proliferation throughout the entire pancreas.
The islets are present in intimate association with ducts, with formation of so-called ductulo-insular complexes.
Focal and diffuse forms of nesidioblastosis have been reported.
Focal lesions may be small (2 - 4 mm) and can easily be overlooked.
Nesidioblastosis is commoner in the body and tail of the pancreas.
It is advocated that the specimen is cut as thinly as possible, and then serial step-wise sections examined microscopically.
Nesidioblastosis is well recognized in the pediatric population as a frequent cause of persistent neonatal hypoglycemia.
Some cases have been reported in adults with persistent hyperinsulinemic hypoglycemia.
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