Histopathology Image of
Granular Cell Tumour 4
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Reactive and hamartomatous lesions:
Fibrolipomatous hamartoma of nerve
Schwannoma (neurilemmoma)
Dermal nerve sheath myxoma
Malignant peripheral nerve sheath tumour Merkel cell (neuroendocrine) carcinoma Malignant primitive neuroectodermal tumour Miscellaneous neuroectodermal tumours presenting in soft tissue |
Visit: Soft Tissue Pathology
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Fine needle aspiration cytology diagnosis of a cutaneous granular cell tumor in a 7-year-old child. A case report. Acta Cytol. 2001 Mar-Apr;45(2).
BACKGROUND:
Granular cell tumors are neoplasms of uncertain histogenesis,
although a neural origin is favored. Most reports on the cytologic
features of granular cell tumors have been on lesions from the
breast or respiratory tract. However, there are only a few reports
on fine needle aspiration (FNA) cytologic diagnosis of cutaneous or
soft tissue granular cell tumors. CASE: A 7-year-old girl presented
with a skin lesion on her right forearm of one year's duration. The
FNA smears showed sheets and clusters of oval to polygonal cells
with an abundant amount of granular cytoplasm. Many single,
scattered cells with similar morphology were seen in the background.
Immunostaining for S-100 protein showed granular cytoplasmic
positivity. The tumor was diagnosed as a benign granular cell tumor.
The histopathology report on the excised lesion confirmed the FNA
diagnosis. CONCLUSION: The cytopathologic features of granular cell
tumors presenting as skin lesions are distinctive enough to allow a
correct diagnosis on FNA cytology. Dermatofibroma-like granular cell tumor.J Cutan Pathol. 2001 Jan;28(1):49-52. BACKGROUND: There have been several reports in the literature of dermatofibromas with granular cells. Here we report a granular cell tumor with the architecture of a dermatofibroma. This is the first report of this histological variant of granular cell tumor. The lesion was a 2.5-cm oval, hyperpigmented plaque present for "years" on the back of a 60-year-old African-American woman. METHODS: The specimen was processed using formalin fixation and paraffin embedding. Tissue sections were stained with hematoxylin and eosin. Immunohistochemical studies were performed with antibodies directed against S-100 protein, neuron-specific enolase, and factor XIIIa. RESULTS: Histopathologic examination revealed granular cells, some of which were spindle shaped, distributed singly and in small groups between collagen bundles resembling a dermatofibroma. Immunohistochemical studies showed the tumor cells to be positive for S-100 and neuron-specific enolase and negative for factor XIIIa. CONCLUSION: The immunohistochemical findings support the diagnosis of a granular cell tumor with a dermatofibroma-like pattern. |