Pancreatic Pathology Online

Pathology of Graft Versus Host Disease of the Pancreas

Dr Sampurna Roy MD                 July 2016

 

Acute pancreatic graft versus host disease (GVHD) may be noted in autopsies of children with congenital immune deficiencies with GVHD of other organs.   

Patients with pancreatic graft versus host disease (GVHD) may have a history of allogeneic bone marrow transplant, fetal liver or thymus transplant, or may have received nonirradiated blood products and had evidence of graft versus host disease (GVHD) in other organs.

Careful attention to pancreatic ducts is necessary for diagnosis.

Microscopic features include lymphocytes around large to medium ducts, damage to ductal epithelium (focal necrosis, reactive nuclear changes, inspissated secretions in duct lumens), and periductal edema.

Immunoperoxidase stain for HLA-DR may show strong-to-moderate staining of duct epithelium.

 

Further reading:

Acute graft-versus-host disease in pancreas transplantation: a comparison of two case presentations and a review of the literature.

Pathology of the pancreas in severe combined immunodeficiency and DiGeorge syndrome: acute graft-versus-host disease and unusual viral infections.

 The pancreas in acute graft versus host disease in man.

Allograft biopsies in management of pancreas transplant recipients.

Acute graft-versus-host reaction in the pancreas.

 

 

 

Dr Sampurna Roy  MD

Consultant  Histopathologist (Kolkata - India)


 

 

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