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Giant cell tumor of
the skull in pediatric patients. Report of two cases.
J Neurosurg. 2007
Jul;107(1 Suppl):69-74.
Giant cell
tumors of the bone are rare, locally aggressive lesions that primarily
affect the epiphyses of long bones. These tumors can occur in the
skull, principally in the sphenoid and temporal bones. Symptoms of
these tumors depend on their site of origin but typically include
headache, pain, visual field defects, and conductive hearing loss.
Histologically, these tumors consist of three cell types: osteoclast-like
multinucleated giant cells; round mononuclear cells resembling
monocytes; and spindle-shaped, fibroblast-like stromal cells.
Radiographically, the tumors appear osteolytic and radiolucent without
a sclerotic border. These tumors typically present in the third to
fourth decades of life and rarely occur in patients under 20 years of
age. The small number of studies of giant cell tumors of the skull has
focused on the adolescent and adult populations. The authors report
two cases of giant cell tumors of the skull in pediatric patients. In
the first case, a 2-year-old girl presented with swelling behind the
right ear. In the second case, a 7-week-old girl presented with a mass
within the external auditory canal. Both patients underwent metastatic
workup and biopsy procedures before resection of the tumor. Both case
reports contribute to the literature of giant cell tumors of the skull
by describing this condition in pediatric patients. To the authors'
knowledge, these cases represent the youngest two patients with giant
cell tumors of the skull yet described.
Giant cell tumor
of the petrous temporal bone with direct invasion into the middle ear.J
Craniofac Surg. 2006 Jul;17(4):797-800.
Giant cell
tumor (GCT) is an uncommon primary bone tumor. The GCT mostly involves
the extremity long bones. Rare is a GCT with tumoral growth in the
cranium, especially other than the sphenoid bone. We herein report a
31-year-old male patient presenting with ipsilateral hearing loss and
episodes of vertigo due to a large lobulated GCT of the right petrous
temporal bone extending into the contiguous middle cranial fossa,
infratemporal space, middle ear and external ear canal. He was treated
with a macroscopically radical tumor excision followed by conventional
megavoltage radiotherapy. The patient remains free of clinical and
radiological evidences of tumoral recurrence six years after
treatment. This experience supports the rationale for the combined
treatment with radical excision plus irradiation toward this rare
neoplasm when vigorous invasion of the skull base is encountered.
Giant cell tumor of
the temporal bone--a case report.BMC
Ear Nose Throat Disord. 2005 Sep 15;5:8.
BACKGROUND:
Giant cell tumor is a benign but locally aggressive bone neoplasm
which uncommonly involves the skull. The petrous portion of the
temporal bone forms a rare location for this tumor. CASE PRESENTATION:
The authors report a case of a large giant cell tumor involving the
petrous and squamous portions of the temporal bone in a 26 year old
male patient. He presented with right side severe hearing loss and
facial paresis. Radical excision of the tumor was achieved but facial
palsy could not be avoided. CONCLUSION: Radical excision of skull base
giant cell tumor may be hazardous but if achieved is the optimal
treatment and may be curative.
Giant cell
tumor of temporal bone: a report of 7 cases.
Lin Chuang Er Bi Yan Hou Ke Za Zhi.
2003 Oct;17(10):596-7, 599.
OBJECTIVE: To
investigate the clinical course, auxiliary examinations, histologic
feature, diagnosis, differential diagnosis and treatment of giant cell
tumor of temporal bone (GCTTB). METHOD: Seven cases of GCTTB, which
arose in temporal bone, were collected from 1990 to 2002 and analyzed
clinicopathologically. RESULT: Seven cases with the GCTTB are
reported, including 3 females, 4 males. The age of 7 patients between
9 to 53 years. Five tumors located in right side temporal bone, two in
left side temporal bone. One patients was pathological I grade, two
I-II grade, and four II grade. The clinical course were different
according to the position of the tumors: including tinnitus 6 cases,
tinnitus with hear loss 5 cases(2 cases with anakus of trouble side
ear), vertigo 1 case, facial paralysis with hear loss 1 case. Radical
resections were performed in five cases and subtotal resections in two
(recurrence, one year after operation, II grade pathologically).
Postoperative Radiotherapy was conducted in three cases. CONCLUSION:
Diagnosis of GCTTB is based on typical histologic features and imaging
as well as clinical information. Complete surgical resection is
believed to be the most suitable treatment for GCTTB and postoperative
radiotherapy may be effective.
A case of
osseous giant cell tumor of the temporal bone and tympanum.HNO.
1988 Mar;36(3):127-8.
The giant-cell
tumor (osteoclastoma) is very rare in the head and neck. Its
histogenesis, diagnosis and classification are difficult. Although it
is considered to be benign, it should be regarded by the clinician as
malignant, because of its high recurrence rate, potential metastases
and the difficulty of total removal. We performed an extended radical
mastoidectomy in a 42-year-old woman with such a tumor of the petrous
bone, primarily to prevent such complications.
Giant
cell tumour of bone in the cavum tympani and petrous bone.Laryngol
Rhinol Otol (Stuttg). 1983
Mar;62(3):103-5.
In the
great majority of cases, the giant-cell tumour of bone (synonymous
with osteoclastoma of bone) is localised at the end of a long tubular
bone. Most of the patients are between 20 and 40 years of age. A case
of a grade II giant-cell tumour in a female patient of 32 years of age
is reported, which was localised in the middle ear and petrous bone.
True
giant-cell tumour of the mastoid. A case report.J
Laryngol Otol.
1981 Aug;95(8):853-8.
The authors
describe a case of a very extensive giant-cell tumour of the mastoid
in a 5 1/2-year-old girl. This is very rare, and it is only the fourth
one documented in the English literature. The age of the patient is of
great importance, as well as the fact that the middle and the inner
ear were not involved, although the tumour was very extensive. Radical
surgical removal of the tumour was performed, as the treatment of
choice, without any signs of recurrence one year post-operatively. The
diagnostic problems of giant-cell lesions of bones are briefly
discussed.
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