Congenital granular cell tumor is a rare tumor which arises from alveolus. We describe a case diagnosed and treated in a neonate. Twenty-eight cases have been reported in Japan, with a male:female ratio of 1:6.3. The location of the tumor was the mandible in 13, the maxilla in 15 and multiple in 1. The left side incisor region was the most common site.

Congenital epulis: a surprise in the neonate.J Can Dent Assoc. 2006 Oct;72(8):747-50.

A newborn infant with congenital epulis can be a striking sight for both parents and health care professionals involved in neonatal care. These tumours of the infant mouth can be remarkably large, occupying much of the oral cavity and posing a risk of airway obstruction or interfering with feeding. Dentists should be able to recognize these swellings as they may be asked to consult and provide information to parents and other practitioners regarding treatment of these lesions.

Obstructive congenital gingival granular cell tumor.Ann Otol Rhinol Laryngol. 2003 Apr;112(4):388-91.

Congenital gingival granular cell tumors (also known as congenital epulis or Neumann's tumor) are rare and always benign intraoral tumors originating from the alveolar ridge. They are typically seen as a mass protruding out of a newborn child's mouth. We report a case of a large obstructive congenital gingival granular cell tumor of the mandibular ridge. The intraoral mass was first detected on a 38-week prenatal ultrasound scan and resulted in neonatal airway obstruction. Complete surgical removal was performed with an uneventful postoperative course. Histologic and immunohistochemical assessments with antibodies against S-100 protein confirmed the diagnosis. The clinical and morphological aspects, differential diagnosis, histogenesis, and treatment are discussed.

Congenital epulis.Pediatrics. 2001 Feb;107(2):E22.

Epulis is a rare tumor of the newborn, also known as granular cell tumor of the newborn or Neumann's tumor. This tumor arises from the mucosa of the gingiva, most commonly from the anterior part of the maxillary alveolar ridge, and is typically seen as a mass protruding out of the newborn child's mouth, which may interfere with respiration or feeding. Epulis is seen only in the newborn and is a different entity from other granular cell tumors. The tumor has a marked female preponderance of 8:1. The recommended treatment is prompt surgical resection. Recurrences of the tumor and damage to future dentition have not been reported, suggesting that radical excision is not warranted. A newborn female with such a mass is described. The tumor was resected using a carbon dioxide laser; the postoperative course was uneventful. On histologic examination, it was composed of diffuse sheets and clusters of polygonal cells containing small round to oval nuclei and abundant coarsely granular cytoplasm. The tumor cells stained positive for vimentin, and negative for S100-protein, actin, desmin, laminin, keratin, estrogen, and progesterone receptors. Electron microscopic examination showed granular cells containing heterogeneous electron-dense granules, lysosomes, and cytoplasmic lipid droplets. The clinical and microscopic features of such tumors are reviewed.