|Pancreatic Pathology Online
Pathology of Pancreatic Disease in AIDS
Dr Sampurna Roy MD July 2016
AIDS can develop pancreatic disease from causes not related to AIDS
or AIDS-specific lesions.
AIDS-specific causes include opportunistic infection, AIDS-associated neoplasia, and medications used to treat complications of AIDS.
Pancreatic involvement is usually part of a widely disseminated tumour and rarely produces clinical symptoms.
Patients with acquired immunodeficiency syndrome (AIDS) can develop biliary and pancreatic disorders, like sclerosing cholangitis and acute pancreatitis and in rare cases pancreas may show chronic pancreatic changes.
Acute pancreatitis, reported in pediatric patients with acquired immune deficiency syndrome (AIDS), is said to have a poor prognosis.
Respiratory failure and sepsis usually constitute the predominant causes of death.
Histopathological examination reveal nonspecific changes, such as edema, inflammation, fibrosis, inspissated material in acini and ducts, and enlarged Langerhans' islet.
Pancreatic opportunistic pathogens include Mycobacterium tuberculosis ; Mycobacterium avium intracellulare, Cryptococcus neoformans ; Candida ; Aspergillus, Toxoplasma gondii ; Pneumocystis carinii ; Cytomegalovirus ; Herpes simplex ; Cryptosporidium and microsporidium.
Although cytomegaloviral pancreatic infection can occur without clinically evident pancreatic disease, cytomegalovirus can cause pancreatitis.
Other opportunistic infections that can cause pancreatitis include Toxoplasma gondii, Cryptococcus neoformans, and Candida.
Mycobacterial infection can produce a pancreatic abscess.
Hepatobiliary or pancreatic duct infection by cytomegalovirus, cryptosporidium,and microsporidium causes irregular ductular narrowing and dilatation.
AIDS-associated pancreatic neoplasms include Kaposi's sarcoma and lymphoma.
Other related posts:
Copyright © 2016 surgical-pathology.com